Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Background Alzheimer's disease (AD) is a neurodegenerative disorder that manifests
sequential Aβ and tau brain pathology with age-dependent onset. Variants in the microglial …

Pathological tau aggregation is a primary neuropathological feature of many
neurodegenerative diseases. Intriguingly, despite the common presence of tau aggregates …

Background The aggregation and spread of α-synuclein (α-Syn) protein and related
neuronal toxicity are the key pathological features of Parkinson's disease (PD) and Lewy …

Solid-like protein deposits found in aged and diseased human brains have revealed a
relationship between insoluble protein accumulations and the resulting deficits in neurologic …

Abnormal filaments of known composition in neurons and glia define many sporadic and
hereditary human neurodegenerative diseases. The pathogenic significance of filamentous …

Tau microtubule-associated proteins, encoded by the MAPT gene, are mainly expressed in
neurons participating in axonal transport and synaptic plasticity. Six major isoforms …

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to
play key roles in Alzheimer's disease pathogenesis and are considered the main …

The colony-stimulating factor 1 receptor (CSF1R) is a key tyrosine kinase transmembrane
receptor modulating microglial homeostasis, neurogenesis, and neuronal survival in the …