Tumour acidosis: from the passenger to the driver's seat
The high metabolic demand of cancer cells leads to an accumulation of H+ ions in the
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …
Manipulating extracellular tumour pH: an effective target for cancer therapy
The pH in tumour cells and the tumour microenvironment has played important roles in
cancer development and treatment. It was thought that both the extracellular and …
cancer development and treatment. It was thought that both the extracellular and …
Interfering with pH regulation in tumours as a therapeutic strategy
D Neri, CT Supuran - Nature reviews Drug discovery, 2011 - nature.com
The high metabolic rate of tumours often leads to acidosis and hypoxia in poorly perfused
regions. Tumour cells have thus evolved the ability to function in a more acidic environment …
regions. Tumour cells have thus evolved the ability to function in a more acidic environment …
Macropinocytosis is an alternative pathway of cysteine acquisition and mitigates sorafenib-induced ferroptosis in hepatocellular carcinoma
Background Macropinocytosis, an important nutrient-scavenging pathway in certain cancer
cells, allows cells to compensate for intracellular amino acid deficiency under nutrient-poor …
cells, allows cells to compensate for intracellular amino acid deficiency under nutrient-poor …
Endocytic reawakening of motility in jammed epithelia
Dynamics of epithelial monolayers has recently been interpreted in terms of a jamming or
rigidity transition. How cells control such phase transitions is, however, unknown. Here we …
rigidity transition. How cells control such phase transitions is, however, unknown. Here we …
Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling
M Koivusalo, C Welch, H Hayashi, CC Scott… - Journal of Cell …, 2010 - rupress.org
Macropinocytosis is differentiated from other types of endocytosis by its unique susceptibility
to inhibitors of Na+/H+ exchange. Yet, the functional relationship between Na+/H+ exchange …
to inhibitors of Na+/H+ exchange. Yet, the functional relationship between Na+/H+ exchange …
Physiology of cell volume regulation in vertebrates
EK Hoffmann, IH Lambert… - Physiological …, 2009 - journals.physiology.org
The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
Wound healing is essential for maintaining the integrity of multicellular organisms. In every
species studied, disruption of an epithelial layer instantaneously generates endogenous …
species studied, disruption of an epithelial layer instantaneously generates endogenous …
Airway acidification initiates host defense abnormalities in cystic fibrosis mice
Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis
transmembrane conductance regulator (CFTR) anion channel. In humans and pigs, the loss …
transmembrane conductance regulator (CFTR) anion channel. In humans and pigs, the loss …
Macropinocytosis: new insights into its underappreciated role in innate immune cell surveillance
J Canton - Frontiers in immunology, 2018 - frontiersin.org
Macropinocytosis has received increasing attention in recent years for its various roles in
nutrient acquisition, immune surveillance, and virus and cancer pathologies. In most cases …
nutrient acquisition, immune surveillance, and virus and cancer pathologies. In most cases …