Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting
motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5 …

Amyotrophic lateral sclerosis (known in the UK as motor neuron disease) is a devastating
illness with uncertain pathogenesis. In this Seminar, we review its natural history, clinical …

Our objective was to develop and validate a new brain-computer interface (BCI) system
suitable for long-term independent home use by people with severe motor disabilities. The …

Most health-care professionals are trained to promote and maintain life and often have
difficulty when faced with the often rapid decline and death of people with terminal illnesses …

Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease of the
motor system. Bulbar symptoms such as dysphagia and dysarthria are frequent features of …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease with no curative
treatment. Considering the devastating nature of the disease, a high prevalence of …

Background Neuromuscular disease causes a progressive decline in ventilatory function
which respiratory muscle training may address. Previous systematic reviews have focussed …

Background The symptoms and their progression in amyotrophic lateral sclerosis (ALS) are
typically studied after the diagnosis has been confirmed. However, many people with ALS …

Objective Respiratory management of patients with end-stage respiratory muscle failure of
neuromuscular disease has evolved from no treatment and inevitable respiratory failure to …

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease with a progressive and
rapid course that, so far, cannot be stopped or reversed. The psychological impact of the …