[HTML][HTML] Biocatalysis

EL Bell, W Finnigan, SP France, AP Green… - Nature Reviews …, 2021 - nature.com
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

Recent trends in biocatalysis

D Yi, T Bayer, CPS Badenhorst, S Wu… - Chemical Society …, 2021 - pubs.rsc.org
Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Deep learning-based kcat prediction enables improved enzyme-constrained model reconstruction

F Li, L Yuan, H Lu, G Li, Y Chen, MKM Engqvist… - Nature Catalysis, 2022 - nature.com
Enzyme turnover numbers (k cat) are key to understanding cellular metabolism, proteome
allocation and physiological diversity, but experimentally measured k cat data are sparse …

Self-play reinforcement learning guides protein engineering

Y Wang, H Tang, L Huang, L Pan, L Yang… - Nature Machine …, 2023 - nature.com
Designing protein sequences towards desired properties is a fundamental goal of protein
engineering, with applications in drug discovery and enzymatic engineering. Machine …

Raman microspectroscopy for microbiology

KS Lee, Z Landry, FC Pereira, M Wagner… - Nature Reviews …, 2021 - nature.com
Raman microspectroscopy offers microbiologists a rapid and non-destructive technique to
assess the chemical composition of individual live microorganisms in near real time. In this …

The crucial role of methodology development in directed evolution of selective enzymes

G Qu, A Li, CG Acevedo‐Rocha, Z Sun… - Angewandte Chemie …, 2020 - Wiley Online Library
Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …

Exploration of nanozymes in viral diagnosis and therapy

J Lee, H Liao, Q Wang, J Han, JH Han, HE Shin… - …, 2022 - Wiley Online Library
Nanozymes are nanomaterials with similar catalytic activities to natural enzymes. Compared
with natural enzymes, they have numerous advantages, including higher physiochemical …

Microbial enzymes will offer limited solutions to the global plastic pollution crisis

J Chow, P Perez‐Garcia, R Dierkes… - Microbial …, 2023 - Wiley Online Library
Global economies depend on the use of fossil‐fuel‐based polymers with 360–400 million
metric tons of synthetic polymers being produced per year. Unfortunately, an estimated 60 …

Recent advances in activity-based probes (ABPs) and affinity-based probes (A f BPs) for profiling of enzymes

H Fang, B Peng, SY Ong, Q Wu, L Li, SQ Yao - Chemical Science, 2021 - pubs.rsc.org
Activity-based protein profiling (ABPP) is a technique that uses highly selective active-site
targeted chemical probes to label and monitor the state of proteins. ABPP integrates the …

A growth selection system for the directed evolution of amine-forming or converting enzymes

S Wu, C Xiang, Y Zhou, MSH Khan, W Liu… - Nature …, 2022 - nature.com
Fast screening of enzyme variants is crucial for tailoring biocatalysts for the asymmetric
synthesis of non-natural chiral chemicals, such as amines. However, most existing …