[HTML][HTML] Biocatalysis
Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …
academia and across the chemical and pharmaceutical industries. Its success has been …
Recent trends in biocatalysis
D Yi, T Bayer, CPS Badenhorst, S Wu… - Chemical Society …, 2021 - pubs.rsc.org
Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …
Deep learning-based kcat prediction enables improved enzyme-constrained model reconstruction
Enzyme turnover numbers (k cat) are key to understanding cellular metabolism, proteome
allocation and physiological diversity, but experimentally measured k cat data are sparse …
allocation and physiological diversity, but experimentally measured k cat data are sparse …
Self-play reinforcement learning guides protein engineering
Y Wang, H Tang, L Huang, L Pan, L Yang… - Nature Machine …, 2023 - nature.com
Designing protein sequences towards desired properties is a fundamental goal of protein
engineering, with applications in drug discovery and enzymatic engineering. Machine …
engineering, with applications in drug discovery and enzymatic engineering. Machine …
Raman microspectroscopy for microbiology
Raman microspectroscopy offers microbiologists a rapid and non-destructive technique to
assess the chemical composition of individual live microorganisms in near real time. In this …
assess the chemical composition of individual live microorganisms in near real time. In this …
The crucial role of methodology development in directed evolution of selective enzymes
Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …
Exploration of nanozymes in viral diagnosis and therapy
Nanozymes are nanomaterials with similar catalytic activities to natural enzymes. Compared
with natural enzymes, they have numerous advantages, including higher physiochemical …
with natural enzymes, they have numerous advantages, including higher physiochemical …
Microbial enzymes will offer limited solutions to the global plastic pollution crisis
J Chow, P Perez‐Garcia, R Dierkes… - Microbial …, 2023 - Wiley Online Library
Global economies depend on the use of fossil‐fuel‐based polymers with 360–400 million
metric tons of synthetic polymers being produced per year. Unfortunately, an estimated 60 …
metric tons of synthetic polymers being produced per year. Unfortunately, an estimated 60 …
Recent advances in activity-based probes (ABPs) and affinity-based probes (A f BPs) for profiling of enzymes
Activity-based protein profiling (ABPP) is a technique that uses highly selective active-site
targeted chemical probes to label and monitor the state of proteins. ABPP integrates the …
targeted chemical probes to label and monitor the state of proteins. ABPP integrates the …
A growth selection system for the directed evolution of amine-forming or converting enzymes
Fast screening of enzyme variants is crucial for tailoring biocatalysts for the asymmetric
synthesis of non-natural chiral chemicals, such as amines. However, most existing …
synthesis of non-natural chiral chemicals, such as amines. However, most existing …