Monoclonal antibody therapies have significantly improved treatment outcomes for patients
with severe asthma; however, a significant disease burden remains. Available biologic …

Arachidonic acid (ARA, 20: 4 n-6) is an n-6 polyunsaturated 20-carbon fatty acid formed by
the biosynthesis from linoleic acid (LA, 18: 2 n-6). This review considers the essential role …

Importance Asthma affects about 7.5% of the adult population. Evidence-based diagnosis,
monitoring, and treatment can improve functioning and quality of life in adult patients with …

Th17 and IL‐17 play important roles in the clearance of extracellular bacterial and fungal
infections. However, strong evidence also implicates the Th17 lineage in several …

The impact of genetic variants on cells challenged in biologically relevant contexts has not
been fully explored. Here, we activated CD4+ T cells from 89 healthy donors and performed …

Patients with moderate-to-severe asthma may now be treated using a variety of monoclonal
antibodies that target key inflammatory cytokines involved in disease pathogenesis. Existing …

Purpose Most asthmatic patients have well controlled symptoms with regular treatment, but
some require much higher doses of inhaled and oral corticosteroids, or in rare cases fail to …

Background: In a subset of severe asthma patients, chronic airway inflammation is
associated with infiltration of neutrophils, Th-17 cells and elevated expression of Th-17 …

Asthma is a complex disease. The heterogeneity of airway inflammation during asthma
indicates there are different mechanisms involved. In order to further study the mechanisms …

Accumulating evidence has implicated the potential of natural compounds in treatment of
asthma. Bixin is a natural food coloring isolated from the seeds of Bixa Orellana, which …