Cancer development and progression occurs in concert with alterations in the surrounding
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …

The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor
immunity by generating type I interferons. In recent decades, we have witnessed that …

Background Cisplatin-based chemotherapy is frequently used to treat advanced gastric
cancer (GC). However, the resistance often occurs with the mechanisms being not well …

The field of non-coding RNA (ncRNA) has made significant progress in understanding the
pathogenesis of diseases and has broadened our knowledge towards their targeting …

The tumor microenvironment has been recently reported to play a pivotal role in sustaining
tumor cells survival and protecting them from immunotherapy and chemotherapy-induced …

Immunotherapies like the adoptive transfer of gene-engineered T cells and immune
checkpoint inhibitors are novel therapeutic modalities for advanced cancers. However, some …

In order to improve the efficacy of conventional radiotherapy, attention has been paid to
immune cells, which not only modulate cancer cell response to therapy but are also highly …

New insights into the field of iron metabolism within the tumor microenvironment have been
uncovered in recent years. Iron promotes the production of reactive oxygen species, which …

Reprogramming of energy metabolism and evading immune are two emerging hallmarks of
cancers. Accumulating evidence suggest that reprogrammed energy metabolism contributes …

Autophagy is a cellular degradation and recycling system, which can interact with
components of innate immune signalling pathways to enhance pathogen clearance, in both …