The tumor microenvironment innately modulates cancer progression
DC Hinshaw, LA Shevde - Cancer research, 2019 - AACR
Cancer development and progression occurs in concert with alterations in the surrounding
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …
cGAS-STING pathway in cancer biotherapy
Y Wang, J Luo, A Alu, X Han, Y Wei, X Wei - Molecular cancer, 2020 - Springer
The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor
immunity by generating type I interferons. In recent decades, we have witnessed that …
immunity by generating type I interferons. In recent decades, we have witnessed that …
Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells
Background Cisplatin-based chemotherapy is frequently used to treat advanced gastric
cancer (GC). However, the resistance often occurs with the mechanisms being not well …
cancer (GC). However, the resistance often occurs with the mechanisms being not well …
[HTML][HTML] Pre-clinical and clinical importance of miR-21 in human cancers: Tumorigenesis, therapy response, delivery approaches and targeting agents
M Hashemi, MSA Mirdamadi, Y Talebi… - Pharmacological …, 2023 - Elsevier
The field of non-coding RNA (ncRNA) has made significant progress in understanding the
pathogenesis of diseases and has broadened our knowledge towards their targeting …
pathogenesis of diseases and has broadened our knowledge towards their targeting …
[HTML][HTML] Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms
G Wang, M Zhang, M Cheng, X Wang, K Li, J Chen… - Cancer Letters, 2021 - Elsevier
The tumor microenvironment has been recently reported to play a pivotal role in sustaining
tumor cells survival and protecting them from immunotherapy and chemotherapy-induced …
tumor cells survival and protecting them from immunotherapy and chemotherapy-induced …
Immunosuppressive cells in cancer: mechanisms and potential therapeutic targets
Y Tie, F Tang, Y Wei, X Wei - Journal of hematology & oncology, 2022 - Springer
Immunotherapies like the adoptive transfer of gene-engineered T cells and immune
checkpoint inhibitors are novel therapeutic modalities for advanced cancers. However, some …
checkpoint inhibitors are novel therapeutic modalities for advanced cancers. However, some …
Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities
A Teresa Pinto, M Laranjeiro Pinto… - Scientific reports, 2016 - nature.com
In order to improve the efficacy of conventional radiotherapy, attention has been paid to
immune cells, which not only modulate cancer cell response to therapy but are also highly …
immune cells, which not only modulate cancer cell response to therapy but are also highly …
Iron metabolism in the tumor microenvironment—Implications for anti-cancer immune response
New insights into the field of iron metabolism within the tumor microenvironment have been
uncovered in recent years. Iron promotes the production of reactive oxygen species, which …
uncovered in recent years. Iron promotes the production of reactive oxygen species, which …
Lactic acid promotes macrophage polarization through MCT-HIF1α signaling in gastric cancer
L Zhang, S Li - Experimental Cell Research, 2020 - Elsevier
Reprogramming of energy metabolism and evading immune are two emerging hallmarks of
cancers. Accumulating evidence suggest that reprogrammed energy metabolism contributes …
cancers. Accumulating evidence suggest that reprogrammed energy metabolism contributes …
Autophagy, the innate immune response and cancer
C Gerada, KM Ryan - Molecular oncology, 2020 - Wiley Online Library
Autophagy is a cellular degradation and recycling system, which can interact with
components of innate immune signalling pathways to enhance pathogen clearance, in both …
components of innate immune signalling pathways to enhance pathogen clearance, in both …