Physiologic alterations seen in obesity commonly impact the pharmacokinetics (PK) and
pharmacodynamics (PD) of antibiotics and may result in suboptimal dosing in this …

Purpose The goal of this review is to explore the role of antimicrobial therapeutic drug
monitoring (TDM), especially in critically ill, obese, and older adults, with a specific focus on …

Beta-lactams (BL) are the first line agents for the antibiotic management of critically ill
patients with sepsis or septic shock. BL are hydrophilic antibiotics particularly subject to …

Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …

Objectives Beta-lactam antibiotics are often subject to therapeutic drug monitoring, but
breakpoints of target attainment are mostly based on expert opinions. Studies that show a …

Therapeutic drug monitoring (TDM) plays an important role in clinical practice. Here,
pharmacokinetics has a decisive influence on the effective antibiotic concentration during …

Purpose To determine whether augmented renal clearance (ARC) impacts negatively on
piperacillin-tazobactam unbound concentrations in critically ill patients receiving 16 g/2 …

As outlined in the “International Guidelines for Management of Sepsis and Septic Shock:
2016,” initial fluid resuscitation and administration of antibiotics are key steps in the early …

Abstract Purpose of Review Beta-lactam antibiotics are commonly prescribed in critically ill
patients for a variety of infectious conditions. Our understanding of how critical illness alters …

The obese patient is at risk of perioperative complications including difficult airway access
(intubation, difficult or impossible ventilation), and postextubation acute respiratory failure …