Activation of the phosphoinositide 3-kinase (PI3K) pathway has been implicated in the
pathogenesis of a variety of cancers. Recently, mutations in the gene encoding the p110α …

Squamous cell carcinoma (SCC) of the lung is a frequent and aggressive cancer type. Gene
amplifications, a known activating mechanism of oncogenes, target the 3q26-qter region as …

Cells communicate with each other and respond to environmental conditions through signal
transduction pathways. In cancer, deregulation of these pathways results in altered …

Lung cancer is a common disease with more than 1.6 million new cases diagnosed
worldwide in 2008. Treatments for patients with advanced disease are rarely curative, and …

The molecular alterations that occur in cells before cancer is manifest are largely uncharted.
Lung carcinoma in situ (CIS) lesions are the pre-invasive precursor to squamous cell …

The fight against lung cancer is greatly compromised by the lack of effective early detection
strategies. Genomic abnormalities and specifically the amplification of chromosomal region …

Lung cancer is the leading cause of cancer mortality worldwide, yet there exists a limited
view of the genetic lesions driving this disease. In this study, an integrated high-resolution …

We previously elucidated the pleotropic role of solute carrier family A1 member 5 (SLC1A5)
as the primary transporter of glutamine (Gln), a modulator of cell growth and oxidative stress …

The phosphoinositide 3-kinase (PI3K) pathway is frequently activated in human cancer and
represents an attractive target for therapies based on small molecule inhibitors. PI3K …

Non-small cell lung cancer (NSCLC) is a devastating disease with poor prognosis. Systemic
chemotherapy has been the mainstay of treatment in advanced disease for many decades …