Cancer progresses through a series of histopathological stages. Progression is thought to
be driven by the accumulation of genetic alterations and consequently gene expression …

Context: Genetic alterations in the phosphatidylinositol-3-kinase (PI3K)/Akt pathway and
their role in thyroid tumor pathogenesis in Chinese people remain undefined. Objective: The …

Aberrant activation of PI3K/AKT signalling represents one of the most common molecular
alterations in lung cancer, though the relative contribution of the single components of the …

Genomic amplification of the distal portion of chromosome 3q, which encodes a number of
oncogenic proteins, is one of the most frequent chromosomal abnormalities in malignancy …

Amplification of oncogenes is an important mechanism that can cause gene overexpression
and contributes to tumor development. The identification of amplified regions might have …

Biomarkers provide a powerful and dynamic approach to understanding the spectrum of
malignancies with applications in observational and analytic epidemiology, randomized …

Prostate cancer is the most commonly diagnosed non-cutaneous neoplasm among
American males and is the second leading cause of cancer-related death. Prostate specific …

Chromosome rearrangement, a hallmark of cancer, has profound effects on carcinogenesis
and tumor phenotype. We used a panel of 60 human cancer cell lines (the NCI-60) as a …

To explore the significance of phosphatidylinositol‐3‐kinase, catalytic, alpha (PIK3CA) in the
carcinogenesis in human lung, mutations and copy number changes were investigated in …

Signaling through the phosphatidylinositol 3-kinase (PI3-kinase) pathway has been
associated with lung tumorigenesis. We examined the association between gene copy …