[HTML][HTML] Increased expression and activation of FAK in small-cell lung cancer compared to non-small-cell lung cancer
F Aboubakar Nana, D Hoton, J Ambroise, M Lecocq… - Cancers, 2019 - mdpi.com
Introduction: Focal adhesion kinase (FAK) plays a crucial role in cancer development and
progression. FAK is overexpressed and/or activated and associated with poor prognosis in …
progression. FAK is overexpressed and/or activated and associated with poor prognosis in …
Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-β signaling in ovarian cancer
JS Sunde, H Donninger, K Wu, ME Johnson… - Cancer research, 2006 - AACR
Ovarian cancer is resistant to the antiproliferative effects of transforming growth factor-β (TGF-
β); however, the mechanism of this resistance remains unclear. We used oligonucleotide …
β); however, the mechanism of this resistance remains unclear. We used oligonucleotide …
Integrative genomics analysis identifies candidate drivers at 3q26-29 amplicon in squamous cell carcinoma of the lung
J Wang, J Qian, MD Hoeksema, Y Zou… - Clinical Cancer …, 2013 - AACR
Abstract Purpose: Chromosome 3q26-29 is a critical region of genomic amplification in lung
squamous cell carcinomas (SCC). Identification of candidate drivers in this region could help …
squamous cell carcinomas (SCC). Identification of candidate drivers in this region could help …
Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy
K Yu, L Toral-Barza, C Shi, WG Zhang… - Cancer biology & …, 2008 - Taylor & Francis
While small molecule inhibitors of the phosphatidylinositide-3-kinase (PI3K) are expected to
impact the development of new cancer therapy, the tumor types and underlying cellular …
impact the development of new cancer therapy, the tumor types and underlying cellular …
Skp2 Gene Copy Number Aberrations Are Common in Non-Small Cell Lung Carcinoma, and Its Overexpression in Tumors with ras Mutation Is a Poor …
CQ Zhu, FH Blackhall, M Pintilie, P Iyengar, N Liu… - Clinical cancer …, 2004 - AACR
Purpose: Skp2 plays a critical role in cell cycle progression, especially at the G1-S transition,
putatively through its control of several cell cycle regulator proteins. The Skp2 gene is …
putatively through its control of several cell cycle regulator proteins. The Skp2 gene is …
Cytogenetic and molecular aspects of lung cancer
AD Panani, C Roussos - Cancer letters, 2006 - Elsevier
Lung cancer is one of the most common cancers worldwide and its pathogenesis is closely
associated with tobacco smoking. Continuous exposure of smoking carcinogens results in …
associated with tobacco smoking. Continuous exposure of smoking carcinogens results in …
[HTML][HTML] ΔNp63α expression is regulated by the phosphoinositide 3-kinase pathway
CE Barbieri, CE Barton, JA Pietenpol - Journal of Biological Chemistry, 2003 - ASBMB
p63 is a homologue of p53 that functions to maintain progenitor cell populations in stratified
epithelia. ΔNp63α is overexpressed in epithelial cancers and has been shown to have …
epithelia. ΔNp63α is overexpressed in epithelial cancers and has been shown to have …
PI3K/AKT/mTOR inhibitors in ovarian cancer
M Mazzoletti, M Broggini - Current medicinal chemistry, 2010 - ingentaconnect.com
Phisiological activation of PI3K pathway is necessary for cells to regulate many different
physiological processes such as transcription, protein synthesis, metabolic responses and …
physiological processes such as transcription, protein synthesis, metabolic responses and …
[HTML][HTML] Identification of novel candidate target genes, including EPHB3, MASP1 and SSTat 3q26.2–q29 in squamous cell carcinoma of the lung
JU Kang, SH Koo, KC Kwon, JW Park, JM Kim - BMC cancer, 2009 - Springer
Background The underlying genetic alterations for squamous cell carcinoma (SCC) and
adenocarcinoma (AC) carcinogenesis are largely unknown. Methods High-resolution array …
adenocarcinoma (AC) carcinogenesis are largely unknown. Methods High-resolution array …
PIK3CA gene amplification in Japanese non-small cell lung cancer
O Kawano, H Sasaki, K Okuda, H Yukiue, T Yokoyama… - Lung Cancer, 2007 - Elsevier
We have investigated 92 non-small cell lung cancer tissues and found 11 PIK3CA
amplification. PIK3CA amplification incidence was significantly higher in male, smoker and …
amplification. PIK3CA amplification incidence was significantly higher in male, smoker and …