Current progress and novel strategies that target CDK12 for drug discovery

P Lei, J Zhang, P Liao, C Ren, J Wang… - European Journal of …, 2022 - Elsevier
CDK12 is a cyclin-dependent kinase that plays critical roles in DNA replication, transcription,
mRNA splicing, and DNA damage repair. CDK12 genomic changes, including mutation …

[HTML][HTML] Function of Deptor and its roles in hematological malignancies

M Morales-Martinez, A Lichtenstein, MI Vega - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Deptor is a protein that interacts with mTOR and that belongs to the mTORC1 and mTORC2
complexes. Deptor is capable of inhibiting the kinase activity of mTOR. It is well known that …

Transcriptomic Analyses of Exercise Training in Alzheimer's Disease Cerebral Cortex

MA Widjaya, YJ Cheng, YM Kuo, CH Liu… - Journal of …, 2023 - content.iospress.com
Transcriptomic Analyses of Exercise Training in Alzheimer’s Disease Cerebral Cortex - IOS
Press You are viewing a javascript disabled version of the site. Please enable Javascript for this …

Clinical significance of tumor infiltrating lymphocytes in association with hormone receptor expression patterns in epithelial ovarian cancer

GH Han, I Hwang, H Cho, K Ylaya, JA Choi… - International journal of …, 2021 - mdpi.com
Hormone receptor expression patterns often correlate with infiltration of specific lymphocytes
in tumors. Specifically, the presence of specific tumor-infiltrating lymphocytes (TILs) with …

[HTML][HTML] Inborn errors of immunity and its clinical significance in children with lymphoma in China: a single-center study

C Yang, N Li, M Zhang, S Huang, L Jin, SG Liu… - Jornal de Pediatria, 2024 - Elsevier
Objective To investigate the incidence, clinical and genetic characteristics of pediatric
lymphoma patients of China with inborn errors of immunity (IEI)-related gene mutations …

Temporal splicing switches in elements of the TNF-pathway identified by computational analysis of transcriptome data for human cell lines

N Genov, A Basti, M Abreu, A Relógio - International Journal of Molecular …, 2019 - mdpi.com
Alternative splicing plays an important role in numerous cellular processes and aberrant
splice decisions are associated with cancer. Although some studies point to a regulation of …

Expression Profile of Selected Antitumor Immune Response Genes in Pediatric Classic Hodgkin Lymphoma

G Gul, M Ceyhan, D Ince, N Olgun… - … & Molecular Morphology, 2022 - journals.lww.com
Classic Hodgkin lymphoma (cHL) is one of the most common pediatric solid tumors and is
responsible for cancer-related deaths in children. Therefore, to modulate the active …

ASSOCIATIONS OF OTUBAIN-1, STAT, SHP AND NF-KB2 EXPRESSION WITH CLINICAL FEATURES IN NON-HODGKIN's LYMPHOMA PATIENTS.

NT Ha, NT Xuan - Journal of Biology/TẠp chí Sinh HỌc, 2024 - search.ebscohost.com
Non-Hodgkin's lymphoma (NHL) is a group of lymphoproliferative disorders characterized
by the abnormal proliferation and accumulation of lymphocytes in the lymphatic system. An …

Associations of\(\textit {OTUBAIN-1, STAT, SHP}\) and\(\textit {NF-KB2}\) expression with clinical features in Non-Hodgkin's lymphoma patients

T Do Thi, HN Trong, XT Nguyen - Academia Journal of Biology, 2024 - vjs.ac.vn
Non-Hodgkin's lymphoma (NHL) is a group of lymphoproliferative disorders characterized
by the abnormal proliferation and accumulation of lymphocytes in the lymphatic system. An …

Clinical significance of tumor infiltrating lymphocytes in association with hormone receptor expression patterns in epithelial ovarian cancer

한관희 - 2021 - ir.ymlib.yonsei.ac.kr
Hormone receptor expression patterns often correlate with infiltration of specific lymphocytes
in tumors. Specifically, the presence of specific tumor infiltrating lymphocytes (TILs) with …