Osteoporosis (OP), characterized by continuous bone loss and increased fracture risk, has
posed a challenge to patients and society. Long-term administration of current …

Osteomyelitis, a debilitating bone infection, presents considerable clinical challenges due to
its intricate etiology and limited treatment options. Despite strides in surgical and …

Plant-derived extracellular nanovesicles contain RNA and proteins with unique and diverse
pharmacological mechanisms. The extracellular nanovesicles encapsulating plant extracts …

Background A growing body of research shows that drug monomers from traditional
Chinese herbal medicines have antineuroinflammatory and neuroprotective effects that can …

To resolve the short-term inflammatory storm after the operation and the long-term
osteointegration deficiency of titanium (Ti) implant as an artificial hip joint, in this work, a …

Osteoclast differentiation and function are critical targets for anti-osteoporosis treatment.
Oxidative stress also plays an important regulatory role in the differentiation of osteoclasts …

Periprosthetic osteolysis (PPO) along with aseptic loosening (AL) caused by wear particles
after artificial joint replacement is the key factor in surgical failure and subsequent revision …

Bone remodeling is essential for the repair and replacement of damaged or aging bones.
Continuous remodeling is necessary to prevent the accumulation of bone damage and to …

Osteoclast is a hematopoietic precursor cell derived from the mononuclear macrophage cell
line, which is the only cell with bone resorption function. Its abnormal activation can cause …

Nuclear factor erythroid-derived factor 2-related factor 2 (Nrf2) is a master regulator of
antioxidant response and protects cells from excessive oxidative stress. Nrf2 emerges as a …