The nonreceptor protein tyrosine kinase Src plays a crucial role in the signal transduction
pathways involved in cell division, motility, adhesion, and survival in both normal and cancer …

The cross-talk between receptor tyrosine kinases and integrin receptors are known to be
crucial for a number of cellular functions. On endothelial cells, an interaction between …

In recent years, tyrosine kinases (TKs) have been recognized as central players and
regulators of cancer cell proliferation, apoptosis, and angiogenesis, and are therefore …

Focal adhesion kinase (FAK) and steroid receptor coactivator (Src) are intracellular
(nonreceptor) tyrosine kinases that physically and functionally interact to promote a variety of …

Abstract microRNAs (miRNAs) are a class of endogenously expressed, small non-coding
RNAs that play an important role in the regulation of gene expression at the post …

BACKGROUND: The recently developed the Src and Abelson (Abl) kinase inhibitor
dasatinib has antitumor effects in epithelial and mesenchymal tumors. Preclinical data have …

Background Quercetin (Que) is reported to induce apoptosis of lung cancer cells. Src is
closely related to the progression of non-small cell lung cancer (NSCLC) and can be …

A sequence of events in vascular and stromal cells maintained in a highly coordinated
manner regulates angiogenesis and tissue remodeling. These processes are mediated by …

Purpose: Signal transducer and activator of transcription-3 (STAT3) is downstream of growth
factor and cytokine receptors, and regulates key oncogenic pathways in nonsmall cell lung …

Locoregional and distant recurrence remains common and usually fatal for patients with
advanced head and neck squamous cell carcinoma (HNSCC). One promising molecular …