Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption
and subsequent release of cellular contents and pro-inflammatory mediators (cytokines) …

Dysregulated host response to infection, which cause life-threatening organ dysfunction,
was defined as sepsis. Sepsis can cause acute and long-term brain dysfunction, namely …

Pore-forming Gasdermin protein-induced pyroptosis in tumor cells promotes anti-tumor
immune response through the release of pro-inflammatory cytokines and immunogenic …

The inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑
like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein …

Pyroptosis is a novel inflammatory form of regulated cell death (RCD), characterized by cell
swelling, membrane rupture, and pro-inflammatory effects. It is recognized as a potent …

Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells with self-renewal
ability and multipotency of osteogenic, chondrogenic, and adipogenic differentiation. MSCs …

Sepsis is a life-threatening organ dysfunction caused by the host's malfunctioning response
to infection. Due to its high mortality rate and medical cost, sepsis remains one of the world's …

Objective Sepsis is the leading cause of death in critically ill patients. The gastrointestinal
tract has long been thought to play an important role in the pathophysiology of sepsis …

Most organs in the body rely on blood flow, and vesicular damage is the leading cause of
injury in multiple organs. The endothelium, as the barriers of vessels, play a critical role in …

Significance: Autophagy is critical to cellular homeostasis. Emergence of the concept of
regulated necrosis, such as necroptosis, ferroptosis, pyroptosis, and mitochondrial …