Endothelial dysfunction in vascular complications of diabetes: a comprehensive review of mechanisms and implications

DR Yang, MY Wang, CL Zhang, Y Wang - Frontiers in Endocrinology, 2024 - frontiersin.org
Diabetic vascular complications are prevalent and severe among diabetic patients,
profoundly affecting both their quality of life and long-term prospects. These complications …

Pyroptosis in sepsis induced organ dysfunction

R Song, S He, Y Wu, S Tan - Current Research in Translational Medicine, 2023 - Elsevier
As an uncontrolled inflammatory response to infection, sepsis and sepsis induced organ
dysfunction are great threats to the lives of septic patients. Unfortunately, the pathogenesis …

[HTML][HTML] Recombinant human angiotensin-converting enzyme 2 plays a protective role in mice with sepsis-induced cardiac dysfunction through multiple signaling …

C Wu, Y Chen, P Zhou, Z Hu - Annals of Translational Medicine, 2023 - ncbi.nlm.nih.gov
Background Sepsis-induced cardiac dysfunction (SICD) is a common complication of sepsis
and contributes to mortality and the complexity of management in patients with sepsis …

Significant difference of differential expression pyroptosis-related genes and their correlations with infiltrated immune cells in sepsis

L Wang, J Zhang, L Zhang, L Hu, J Tian - Frontiers in Cellular and …, 2022 - frontiersin.org
Background Sepsis is regarded as a life-threatening organ dysfunction syndrome that
responds to infection. Pyroptosis, a unique form of programmed cell death, is characterized …

Genome-wide exploration of a pyroptosis-related gene module along with immune cell infiltration patterns in bronchopulmonary dysplasia

L Chen, C Shi, G Zhou, X Yang, Z Xiong, X Ma… - Frontiers in …, 2023 - frontiersin.org
Pyroptosis plays a crucial role in bronchopulmonary dysplasia (BPD) and is associated with
various lung injury illnesses. However, the function of pyroptosis-related genes (PRGs) in …

Ubiquitination in pyroptosis pathway: A potential therapeutic target for sepsis

Y Liao, W Zhang, M Zhou, C Zhu, Z Zou - Cytokine & Growth Factor …, 2024 - Elsevier
Sepsis remains a significant clinical challenge, causing numerous deaths annually and
representing a major global health burden. Pyroptosis, a unique form of programmed cell …

HMGB1/Caspase-1/GSDMD 信号轴介导肝细胞焦亡在肝脏缺血-再灌注损伤中的作用.

胡莎莎, 刘钰, 王朝阳, 杨爽… - … /Qi Guan Yi Zhi, 2022 - search.ebscohost.com
目的探讨高迁移率族蛋白1 (HMGB1)/半胱氨酸天冬氨酸蛋白酶(Caspase)-1/Gasdermin D
(GSDMD) 信号轴介导肝细胞焦亡在肝脏缺血-再灌注损伤(IRI) 中的作用. 方法将C57BL/6 …

Bulk and Single‐Cell Transcriptome Analyses Revealed That the Pyroptosis of Glioma‐Associated Macrophages Participates in Tumor Progression and …

L Li, L Wu, X Yin, C Li, Z Hua - Oxidative medicine and cellular …, 2022 - Wiley Online Library
Glioma is the most common of all central nervous system (CNS) malignancies and is
associated with a poor prognosis. Pyroptosis has been proven to be associated with the …

miR-20b attenuates airway inflammation by regulating TXNIP and NLRP3 inflammasome in ovalbumin-induced asthmatic mice

J Huang, X Ruan, T Tian, Y Xu, L Hu, Y Sun - Journal of Asthma, 2023 - Taylor & Francis
Objectives Asthma is a chronic inflammatory disorder of the airway and is associated with
pyroptosis. microRNAs (miRNAs) underlie pathogenic mechanism in asthma. This study is …

GDF3 protects mice against sepsis-induced acute lung injury by suppression of macrophage pyroptosis

J Lei, L Wang, L Zou, H Wang, Y Zhang, S Liu, M Pan… - Pharmaceuticals, 2024 - mdpi.com
Sepsis-induced ALI is marked by physiological, pathological, and biochemical irregularities
caused by infection. Growth differentiation factor 3 (GDF3) is closely associated with the …