Sepsis‐induced brain dysfunction: pathogenesis, diagnosis, and treatment
S Pan, Z Lv, R Wang, H Shu, S Yuan… - … medicine and cellular …, 2022 - Wiley Online Library
Dysregulated host response to infection, which cause life‐threatening organ dysfunction,
was defined as sepsis. Sepsis can cause acute and long‐term brain dysfunction, namely …
was defined as sepsis. Sepsis can cause acute and long‐term brain dysfunction, namely …
Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases
M Chen, R Rong, X Xia - Journal of neuroinflammation, 2022 - Springer
Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption
and subsequent release of cellular contents and pro-inflammatory mediators (cytokines) …
and subsequent release of cellular contents and pro-inflammatory mediators (cytokines) …
Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response
Z Li, F Mo, Y Wang, W Li, Y Chen, J Liu… - Nature …, 2022 - nature.com
Pore-forming Gasdermin protein-induced pyroptosis in tumor cells promotes anti-tumor
immune response through the release of pro-inflammatory cytokines and immunogenic …
immune response through the release of pro-inflammatory cytokines and immunogenic …
Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases
X Zhang, Z Wang, Y Zheng, Q Yu… - International …, 2023 - spandidos-publications.com
The inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑
like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein …
like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein …
Pyroptosis in renal inflammation and fibrosis: current knowledge and clinical significance
Y Liu, H Lei, W Zhang, Q Xing, R Liu, S Wu, Z Liu… - Cell Death & …, 2023 - nature.com
Pyroptosis is a novel inflammatory form of regulated cell death (RCD), characterized by cell
swelling, membrane rupture, and pro-inflammatory effects. It is recognized as a potent …
swelling, membrane rupture, and pro-inflammatory effects. It is recognized as a potent …
Fecal microbiota transplantation and short-chain fatty acids reduce sepsis mortality by remodeling antibiotic-induced gut microbiota disturbances
X Lou, J Xue, R Shao, Y Yang, D Ning, C Mo… - Frontiers in …, 2023 - frontiersin.org
Objective Sepsis is the leading cause of death in critically ill patients. The gastrointestinal
tract has long been thought to play an important role in the pathophysiology of sepsis …
tract has long been thought to play an important role in the pathophysiology of sepsis …
Mesenchymal stem cell-derived apoptotic bodies: biological functions and therapeutic potential
H Tang, H Luo, Z Zhang, D Yang - Cells, 2022 - mdpi.com
Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells with self-renewal
ability and multipotency of osteogenic, chondrogenic, and adipogenic differentiation. MSCs …
ability and multipotency of osteogenic, chondrogenic, and adipogenic differentiation. MSCs …
[HTML][HTML] The “self-sacrifice” of immunecells in sepsis
X Wen, B Xie, S Yuan, J Zhang - Frontiers in immunology, 2022 - frontiersin.org
Sepsis is a life-threatening organ dysfunction caused by the host's malfunctioning response
to infection. Due to its high mortality rate and medical cost, sepsis remains one of the world's …
to infection. Due to its high mortality rate and medical cost, sepsis remains one of the world's …
[HTML][HTML] The role of pyroptosis in endothelial dysfunction induced by diseases
J Ju, Y Liu, H Liang, B Yang - Frontiers in Immunology, 2023 - frontiersin.org
Most organs in the body rely on blood flow, and vesicular damage is the leading cause of
injury in multiple organs. The endothelium, as the barriers of vessels, play a critical role in …
injury in multiple organs. The endothelium, as the barriers of vessels, play a critical role in …
The interplay between autophagy and regulated necrosis
Significance: Autophagy is critical to cellular homeostasis. Emergence of the concept of
regulated necrosis, such as necroptosis, ferroptosis, pyroptosis, and mitochondrial …
regulated necrosis, such as necroptosis, ferroptosis, pyroptosis, and mitochondrial …