Genome-wide association studies (GWAS) have emerged as an important tool for
discovering regions of the genome that harbor genetic variants that confer risk for different …

The study of recent natural selection in human populations has important applications to
human history and medicine. Positive natural selection drives the increase in beneficial …

It is particularly meaningful to investigate natural selection in African Americans (AfA) due to
the high mortality their African ancestry has experienced in history. In this study, we …

Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in A sia,
where J apan and K orea have the highest incidence in the world. Gastric cancer is …

Background RNA-sequencing (RNA-seq) is a powerful technique for the identification of
genetic variants that affect gene-expression levels, either through expression quantitative …

Genome-wide association studies have identified a SNP, rs2294008, on 8q24. 3 within the
prostate stem cell antigen (PSCA) gene, as a risk factor for bladder cancer. To fine-map this …

Purpose The known epithelial ovarian cancer (EOC) susceptibility genes account for less
than 50% of the heritable risk of ovarian cancer suggesting that other susceptibility genes …

Osteosarcoma (OS) is the most commonly diagnosed malignant bone tumor in humans and
dogs, characterized in both species by extremely complex karyotypes exhibiting high …

Men are three to four times more likely to get bladder cancer than women. The gender
disparity characterizing bladder cancer diagnoses has been investigated. One hypothesis is …

Abstract miRNAs play important roles in numerous cellular processes, including
development, proliferation, apoptosis, and carcinogenesis. Because altered expression and …