Diverse functions of cytochrome c in cell death and disease

Z Zhou, T Arroum, X Luo, R Kang, YJ Lee… - Cell Death & …, 2024 - nature.com
The redox-active protein cytochrome c is a highly positively charged hemoglobin that
regulates cell fate decisions of life and death. Under normal physiological conditions …

Live-cell visualization of cytochrome c: a tool to explore apoptosis

J Pessoa - Biochemical Society Transactions, 2021 - portlandpress.com
Apoptosis dysfunction is associated with several malignancies, including cancer and
autoimmune diseases. Apoptosis restoration could be an attractive therapeutic approach to …

Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid–liquid phase separation

K González-Arzola, A Díaz-Quintana… - Nature structural & …, 2022 - nature.com
The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered
unrelated processes, yet cytochrome c (C c) migrates to the nucleus and even the nucleolus …

De novo sequencing and construction of a unique antibody for the recognition of alternative conformations of cytochrome c in cells

F Tomasina, J Martínez, A Zeida… - Proceedings of the …, 2022 - National Acad Sciences
Cytochrome c (cyt c) can undergo reversible conformational changes under biologically
relevant conditions. Revealing these alternative cyt c conformers at the cell and tissue level …

The Histone Chaperones SET/TAF‐1β and NPM1 Exhibit Conserved Functionality in Nucleosome Remodeling and Histone Eviction in a Cytochrome c‐Dependent …

P Buzón, A Velázquez‐Cruz… - Advanced …, 2023 - Wiley Online Library
Chromatin homeostasis mediates essential processes in eukaryotes, where histone
chaperones have emerged as major regulatory factors during DNA replication, repair, and …

SET protein as an epigenetics target

G Silva, TM Milan, PS Chagas, GL Trevisan… - …, 2024 - Future Medicine
The SET gene has four transcripts reported in NCBI, coding two isoforms of SET proteins.
The most known function of SET protein is inhibiting protein phosphatase 2A, a tumor …

New insights on the regulation of the insulin-degrading enzyme: role of microRNAs and RBPs

Y Martín-Martín, A Pérez-García, M Torrecilla-Parra… - Cells, 2022 - mdpi.com
The evident implication of the insulin-degrading enzyme (IDE) in Alzheimer's disease (AD)
and type 2 diabetes mellitus (T2DM), among its capacity to degrade insulin and amyloid-β …

Structural Biology in Cells by In-cell NMR

Y Fleischmann, J Gerez, R Riek - 2023 - books.rsc.org
In-cell NMR has the potential to study protein structure and dynamics within a cell. In this
chapter, the history of in-cell NMR and the various in-cell NMR methods established along …

Membraneless organelles: a smart design for metabolic control

I Díaz‐Moreno, MA De la Rosa - FEBS Open bio, 2021 - Wiley Online Library
While most organelles are surrounded by membranes, cells also contain membraneless
organelles, which remain separated in the cell by avoiding the mixture of their components …

Entering the second decade: FEBS Open Bio in 2022

DE Wright, MA De la Rosa - FEBS Open bio, 2022 - Wiley Online Library
Entering the second decade: FEBS Open Bio in 2022 - Wright - 2022 - FEBS Open Bio - Wiley
Online Library Skip to Article Content Skip to Article Information FEBS Press FEBS Press …