Towards glycan foldamers and programmable assemblies

S Djalali, N Yadav, M Delbianco - Nature Reviews Materials, 2024 - nature.com
Natural biopolymers have inspired the development of synthetic analogues that can adopt
defined conformations and assemble into 3D architectures. These compounds are mainly …

Chemical modification of hyaluronan and their biomedical applications

V Hintze, M Schnabelrauch, S Rother - Frontiers in Chemistry, 2022 - frontiersin.org
Hyaluronan, the extracellular matrix glycosaminoglycan, is an important structural
component of many tissues playing a critical role in a variety of biological contexts. This …

Precision native polysaccharides from living polymerization of anhydrosugars

L Wu, Z Zhou, D Sathe, J Zhou, S Dym, Z Zhao… - Nature Chemistry, 2023 - nature.com
The composition, sequence, length and type of glycosidic linkage of polysaccharides
profoundly affect their biological and physical properties. However, investigation of the …

Promoter‐Controlled Synthesis and Conformational Analysis of Cyclic Mannosides up to a 32‐mer

X Li, C Di Carluccio, H Miao, L Zhang… - Angewandte Chemie …, 2023 - Wiley Online Library
Cyclodextrins are widely used as carriers of small molecules for drug delivery owing to their
remarkable host properties and excellent biocompatibility. However, cyclic oligosaccharides …

Chemical synthesis of polysaccharides

S Wang, Y Yang, Q Zhu, GQ Lin, B Yu - Current Opinion in Chemical …, 2022 - Elsevier
Here we summarize the chemical syntheses of glycans containing over 20 monosaccharide
units, with the recent syntheses of ultra-long glycans, including a 92mer arabinogalactan, a …

Harnessing the dual role of polysaccharides in treating gastrointestinal diseases: As therapeutics and polymers for drug delivery

L Corrie, M Gulati, A Awasthi, S Vishwas, J Kaur… - Chemico-Biological …, 2022 - Elsevier
Polysaccharides (PS) represent a broad class of polymer-based compounds that have been
extensively researched as therapeutics and excipients for drug delivery. As pharmaceutical …

On resin synthesis of sulfated oligosaccharides

T Tyrikos-Ergas, ET Sletten, JY Huang… - Chemical …, 2022 - pubs.rsc.org
Sulfated glycans are involved in many biological processes, making well-defined sulfated
oligosaccharides highly sought molecular probes. These compounds are a considerable …

Synthetic phosphoethanolamine-modified oligosaccharides reveal the importance of glycan length and substitution in biofilm-inspired assemblies

T Tyrikos-Ergas, S Gim, JY Huang… - Nature …, 2022 - nature.com
Bacterial biofilm matrices are nanocomposites of proteins and polysaccharides with
remarkable mechanical properties. Efforts understanding and tuning the protein component …

Alternative processes to produce chitin, chitosan, and their oligomers

JD Giraldo, Y García, M Vera, KA Garrido-Miranda… - Carbohydrate …, 2024 - Elsevier
Sustainable recovery of chitin and its derivatives from shellfish waste will be achieved when
the industrial production of these polymers is achieved with a high control of their molecular …

Protecting group principles suited to late stage functionalization and global deprotection in oligosaccharide synthesis

D Dhara, A Dhara, PV Murphy, LA Mulard - Carbohydrate research, 2022 - Elsevier
Chemical synthesis is a powerful tool to access homogeneous complex glycans, which
relies on protecting group (PG) chemistry. However, the overall efficiency of chemical glycan …