[HTML][HTML] Blood–Brain barrier, cell junctions, and tumor microenvironment in brain metastases, the biological prospects and dilemma in therapies
Z Guan, H Lan, X Cai, Y Zhang, A Liang… - Frontiers in Cell and …, 2021 - frontiersin.org
Brain metastasis is the most commonly seen brain malignancy, frequently originating from
lung cancer, breast cancer, and melanoma. Brain tumor has its unique cell types, anatomical …
lung cancer, breast cancer, and melanoma. Brain tumor has its unique cell types, anatomical …
[HTML][HTML] The prospect of combination therapies with the third-generation EGFR-TKIs to overcome the resistance in NSCLC
S Li, S Zhu, H Wei, P Zhu, Y Jiao, M Yi, J Gong… - Biomedicine & …, 2022 - Elsevier
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) bring significant
benefits to non-small cell lung cancer patients with EGFR mutations, which represent a …
benefits to non-small cell lung cancer patients with EGFR mutations, which represent a …
[HTML][HTML] Correlation between EGFR mutation status and the incidence of brain metastases in patients with non-small cell lung cancer
L Li, S Luo, H Lin, H Yang, H Chen, Z Liao… - Journal of thoracic …, 2017 - ncbi.nlm.nih.gov
Background Lung cancer is the leading cause of cancer-related death worldwide. Numerous
studies have been performed to investigate the correlation between epidermal growth factor …
studies have been performed to investigate the correlation between epidermal growth factor …
[HTML][HTML] EGFR and KRAS Mutations Predict the Incidence and Outcome of Brain Metastases in Non-Small Cell Lung Cancer
P Tomasini, C Serdjebi, N Khobta, P Metellus… - International journal of …, 2016 - mdpi.com
Background: Lung cancer is the leading cause of brain metastases (BM). The identification
of driver oncogenes and matched targeted therapies has improved outcome in non-small …
of driver oncogenes and matched targeted therapies has improved outcome in non-small …
A novel mTORC1/2 inhibitor (MTI-31) inhibits tumor growth, epithelial–mesenchymal transition, metastases, and improves antitumor immunity in preclinical models of …
Q Zhang, Y Zhang, Y Chen, J Qian, X Zhang… - Clinical Cancer Research, 2019 - AACR
Purpose: We aimed to investigate efficacy and mechanism of MTI-31 (LXI-15029), a novel
mTORC1/mTORC2 inhibitor currently in human trial (NCT03125746), in non–small cell lung …
mTORC1/mTORC2 inhibitor currently in human trial (NCT03125746), in non–small cell lung …
[HTML][HTML] Association of molecular status and metastatic organs at diagnosis in patients with stage IV non-squamous non-small cell lung cancer
C Kuijpers, LEL Hendriks, JL Derks, AMC Dingemans… - Lung Cancer, 2018 - Elsevier
Objectives Biological predisposition for specific metastatic organs might differ between
molecular subgroups of lung cancer. We aimed to assess the association between …
molecular subgroups of lung cancer. We aimed to assess the association between …
[HTML][HTML] Multi-channel multi-task deep learning for predicting EGFR and KRAS mutations of non-small cell lung cancer on CT images
Y Dong, L Hou, W Yang, J Han, J Wang… - … imaging in medicine …, 2021 - ncbi.nlm.nih.gov
Background Predicting the mutation statuses of 2 essential pathogenic genes [epidermal
growth factor receptor (EGFR) and Kirsten rat sarcoma (KRAS)] in non-small cell lung cancer …
growth factor receptor (EGFR) and Kirsten rat sarcoma (KRAS)] in non-small cell lung cancer …
[HTML][HTML] Mutational characteristics of bone metastasis of lung cancer
X Huang, X Shi, D Huang, B Li, N Lin… - Annals of Palliative …, 2021 - apm.amegroups.org
Background: Roughly 30–40% of lung cancer (LC) patients develop bone metastasis during
the course of disease. The genetic differences between primary LC and matched bone …
the course of disease. The genetic differences between primary LC and matched bone …
[HTML][HTML] The impact of EGFR mutations on the incidence and survival of stages I to III NSCLC patients with subsequent brain metastasis
Previous studies have demonstrated the association between EGFR mutations and distant
metastasis. However, the association for subsequent brain metastasis (BM) in stages I-III …
metastasis. However, the association for subsequent brain metastasis (BM) in stages I-III …
[HTML][HTML] Phosphorylation of CAP1 regulates lung cancer proliferation, migration, and invasion
J Zeng, X Li, L Liang, H Duan, S Xie… - Journal of Cancer …, 2022 - Springer
Purpose Cyclase-associated protein 1 (CAP1) is a ubiquitous protein which regulates actin
dynamics. Previous studies have shown that S308 and S310 are the two major …
dynamics. Previous studies have shown that S308 and S310 are the two major …