Although substance use is widespread across the lifespan from early adolescence to older
adulthood, the prevalence of substance use disorder (SUD) differs between age groups …

Adolescence is a critical juncture when initiation of drug use intersects with profound
developmental changes in the brain. Adolescent drug use increases the risk to develop …

Kratom is a medicinal plant that exhibits promising results as an opiate substitute. However,
there is little information regarding the abuse profile of its main psychoactive constituent …

Adolescents are at increased risk to develop substance use disorders and suffer from
relapse throughout life. Targeted weakening of drug-associated memories has been shown …

Adolescence marks a particularly vulnerable period to developing substance use disorders.
Human and rodent studies suggest that hypersensitivity to reward may contribute towards …

Rationale Drug use during adolescence results in a life-long risk to develop substance-use
disorders. Adolescent rats are sensitive to different drug-associated cues, compared to …

Aims This study aims to investigate the pharmacological effects and the underlying
mechanism of cannabidiol (CBD) on methamphetamine (METH)‐induced relapse and …

Mitragynine (MG) is a pharmacologically active alkaloid derived from the leaves of Mitragyna
speciosa Korth (Kratom). This plant has sparked significant interest as a potential alternative …

Relapse is a major obstacle to curb the ongoing epidemic of prescription opioid abuse. We
and others previously demonstrated that oxycodone seeking in adult rats progressively …