HuR as a molecular target for cancer therapeutics and immune-related disorders
M Majumder, P Chakraborty, S Mohan… - Advanced drug delivery …, 2022 - Elsevier
The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …
Functional interplay between RNA-binding protein HuR and microRNAs
S Srikantan, K Tominaga… - Current Protein and …, 2012 - ingentaconnect.com
The mammalian RNA-binding protein (RBP) HuR associates with numerous mRNAs
encoding proteins with roles in cell division, cell survival, immune response, and …
encoding proteins with roles in cell division, cell survival, immune response, and …
HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP
Some mitochondrial long noncoding RNAs (lncRNAs) are encoded by nuclear DNA, but the
mechanisms that mediate their transport to mitochondria are poorly characterized. Using …
mechanisms that mediate their transport to mitochondria are poorly characterized. Using …
LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR
The function of the vast majority of mammalian long noncoding (lnc) RNAs remains
unknown. Here, analysis of a highly abundant mammalian lncRNA, OIP5-AS1, known as …
unknown. Here, analysis of a highly abundant mammalian lncRNA, OIP5-AS1, known as …
7SL RNA represses p53 translation by competing with HuR
Abstract Noncoding RNAs (ncRNAs) and RNA-binding proteins are potent post-
transcriptional regulators of gene expression. The ncRNA 7SL is upregulated in cancer …
transcriptional regulators of gene expression. The ncRNA 7SL is upregulated in cancer …
[HTML][HTML] miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth
M Mihailovich, M Bremang, V Spadotto… - Nature …, 2015 - nature.com
The synergism between c-MYC and miR-17-19b, a truncated version of the miR-17-92
cluster, is well-documented during tumor initiation. However, little is known about miR-17 …
cluster, is well-documented during tumor initiation. However, little is known about miR-17 …
[HTML][HTML] PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR
Y Ke, Y Han, X Guo, J Wen, K Wang, X Jiang… - Nature …, 2017 - nature.com
Abstract Poly (ADP-ribosyl) ation (PARylation) is mainly catalysed by poly-ADP-ribose
polymerase 1 (PARP1), whose role in gene transcription modulation has been well …
polymerase 1 (PARP1), whose role in gene transcription modulation has been well …
Systematic analysis of AU-rich element expression in cancer reveals common functional clusters regulated by key RNA-binding proteins
Defects in AU-rich elements (ARE)-mediated posttranscriptional control can lead to several
abnormal processes that underlie carcinogenesis. Here, we performed a systematic analysis …
abnormal processes that underlie carcinogenesis. Here, we performed a systematic analysis …
Targeting the HuR oncogenic role with a new class of cytoplasmic dimerization inhibitors
N Filippova, X Yang, S Ananthan, J Calano, V Pathak… - Cancer research, 2021 - AACR
The development of novel therapeutics that exploit alterations in the activation state of key
cellular signaling pathways due to mutations in upstream regulators has generated the field …
cellular signaling pathways due to mutations in upstream regulators has generated the field …
HuR Regulates Alternative Splicing of the TRA2β Gene in Human Colon Cancer Cells under Oxidative Stress
Y Akaike, K Masuda, Y Kuwano, K Nishida… - … and cellular biology, 2014 - Taylor & Francis
Hu antigen R (HuR) regulates stress responses through stabilizing and/or facilitating the
translation of target mRNAs. The human TRA2 β gene encodes splicing factor transformer …
translation of target mRNAs. The human TRA2 β gene encodes splicing factor transformer …