Hypoxia: overview on hypoxia-mediated mechanisms with a focus on the role of HIF genes
AA Tirpe, D Gulei, SM Ciortea, C Crivii… - International journal of …, 2019 - mdpi.com
Hypoxia represents a frequent player in a number of malignancies, contributing to the
development of the neoplastic disease. This review will discuss the means by which hypoxia …
development of the neoplastic disease. This review will discuss the means by which hypoxia …
Role of mitochondria in radiation responses: epigenetic, metabolic, and signaling impacts
D Averbeck, C Rodriguez-Lafrasse - International journal of molecular …, 2021 - mdpi.com
Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …
damage and their management by repair mechanisms. However, molecular biology studies …
Engineering macrophage exosome disguised biodegradable nanoplatform for enhanced sonodynamic therapy of glioblastoma
Sonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation
damage to normal tissues, and thus emerges as a promising cancer therapeutic modality for …
damage to normal tissues, and thus emerges as a promising cancer therapeutic modality for …
2D MoS2‐Based Nanomaterials for Therapeutic, Bioimaging, and Biosensing Applications
Abstract Molybdenum disulfide (MoS2), a typical layered 2D transition metal dichalcogenide,
has received colossal interest in the past few years due to its unique structural …
has received colossal interest in the past few years due to its unique structural …
Role of metabolism in cancer cell radioresistance and radiosensitization methods
L Tang, F Wei, Y Wu, Y He, L Shi, F Xiong… - Journal of Experimental …, 2018 - Springer
Background Radioresistance is a major factor leading to the failure of radiotherapy and poor
prognosis in tumor patients. Following the application of radiotherapy, the activity of various …
prognosis in tumor patients. Following the application of radiotherapy, the activity of various …
Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation
SY Lee, EK Jeong, MK Ju, HM Jeon, MY Kim, CH Kim… - Molecular cancer, 2017 - Springer
Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …
[HTML][HTML] Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
C Wigerup, S Påhlman, D Bexell - Pharmacology & therapeutics, 2016 - Elsevier
Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …
Ultrasound triggered tumor oxygenation with oxygen-shuttle nanoperfluorocarbon to overcome hypoxia-associated resistance in cancer therapies
Tumor hypoxia is known to be one of critical reasons that limit the efficacy of cancer
therapies, particularly photodynamic therapy (PDT) and radiotherapy (RT) in which oxygen …
therapies, particularly photodynamic therapy (PDT) and radiotherapy (RT) in which oxygen …
Adaptive mechanisms of tumor therapy resistance driven by tumor microenvironment
Cancer is a disease which frequently has a poor prognosis. Although multiple therapeutic
strategies have been developed for various cancers, including chemotherapy, radiotherapy …
strategies have been developed for various cancers, including chemotherapy, radiotherapy …
Regulation of pyruvate metabolism and human disease
LR Gray, SC Tompkins, EB Taylor - Cellular and molecular life sciences, 2014 - Springer
Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …
metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in …