Malignant bone tumor is one of the major bone diseases. The treatment of such a bone
disease typically requires the removal of bone tumor and regeneration of tumor‐initiated …

Reprogramming of cell metabolism is essential for tumorigenesis, and is regulated by a
complex network, in which PKM2 plays a critical role. PKM2 exists as an inactive monomer …

Radiotherapy is a common modality for more than half of cancer patients. Classically,
radiation is known as a strategy to kill cancer cells via direct interaction with DNA or …

Culture of cancerous cells in standard monolayer conditions poorly mirrors growth in three-
dimensional architectures typically observed in a wide majority of cancers of different …

A general therapeutic strategy to treat breast cancer is attractive as different subtypes of
breast cancers often exhibit distinct response to existing cancer therapeutics. To this end, we …

Radiotherapy is a mainstay treatment for many types of cancer and kills cancer cells via
generation of reactive oxygen species (ROS). Incorporating radiation with pharmacological …

The off-target distribution of anticancer nanoparticles to fibroblasts creates a barrier to the
effective treatment of desmoplastic tumors. However, we hypothesized that this nanoparticle …

Ionizing radiation (IR), such as X-rays and gamma (γ)-rays, mediates various forms of cancer
cell death such as apoptosis, necrosis, autophagy, mitotic catastrophe, and senescence …

The successful treatment of human cancers by immunotherapy has been made possible by
breakthroughs in the discovery of immune checkpoint regulators, including CTLA-4 and PD …

Sirtuins are Class III protein deacetylases with seven conserved isoforms. In general,
Sirtuins are highly activated under cellular stress conditions in which NAD+ levels are …