Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to
radiation therapy and cancer progression via several molecular and physiologic …

Accelerated glucose uptake and “aerobic glycolysis” of tumor cells generates a high-level
lactate in extracellular space and within tumor tissue, which is thought to be a hallmark of …

Immune checkpoint blockade (ICB) has demonstrated an impressive outcome in patients
with metastatic melanoma, yet, durable complete response; even with …

Highlights•PFCs efficiently deliver O 2 to tumor tissues, and can alleviate hypoxia.•PFC-
based O 2 nanocarriers increase 1 O 2 lifetime, enhancing PDT/SDT, radiotherapy and …

Tumor cells prefer glycolysis (Warburg effect) during the proliferation and metastasis. The
precise mechanism remains largely unknown. Here, we demonstrated that pyruvate …

Chemo-/radioresistance is a major obstacle in clinical oncology. The precise failure
mechanisms of chemo-/radioresistance are multifactorial failures. It is now widely accepted …

Radiation therapy (RT) is commonly used for the treatment of localized prostate cancer
(PCa). However, cancer cells often develop resistance to radiation through unknown …

Surgical resection, as the most efficient treatment for bone tumor, still faces a dilemma
between the complete removal of tumor tissue and the maximum reservation of healthy bone …

Abstract Background Lactate dehydrogenase A (LDHA) is overexpressed and associated
with poor prognosis in many kinds of cancer. In the current study, we evaluated the …

Hypoxia occurs in a series of supraphysiological circumstances, for instance, sleep
disorders, myocardial infarction and cerebral stroke, that can induce a systematic …