The members of the transforming growth factor β (TGF-β) superfamily are essential
regulators of cell differentiation, phenotype and function, and have been implicated in the …

Type I programmed cell death (PCD) or apoptosis is critical for cellular self-destruction for a
variety of processes such as development or the prevention of oncogenic transformation …

Most myocardial pathologic conditions are associated with cardiac fibrosis, the expansion of
the cardiac interstitium through deposition of extracellular matrix (ECM) proteins. Although …

Oxygen deprivation leads to the accumulation of misfolded proteins in the endoplasmic
reticulum (ER), causing ER stress. Under conditions of ER stress, inhibition of protein …

The adult mammalian heart has negligible regenerative capacity. Following myocardial
infarction, sudden necrosis of cardiomyocytes triggers an intense inflammatory reaction that …

The transforming growth factor-ß (TGF-ß) superfamily proteins, comprising more than 40
members (broadly divided into the TGF-ßs/activins/nodal family and the bone …

Cardiac fibrosis is a major pathogenic factor in a variety of cardiovascular diseases and
refers to an excessive deposition of extracellular matrix components in the heart, which …

Aims Results from clinical trials suggest that cardiac function after acute myocardial
infarction (AMI) can be enhanced by an intracoronary infusion of autologous unselected …

BACKGROUND: Despite advances in treatment, myocardial infarction (MI) is a leading
cause of heart failure and death worldwide, with both ischemia and reperfusion (I/R) causing …

Aims MicroRNAs (miRNAs) have been implicated in the pathogenesis of pulmonary
hypertension (PH), a multifactorial and progressive condition associated with an increased …