Much progress has been made in the 26 years since initial studies of the first purified
acetylcholine receptors (AChRs) led to the discovery that an antibody‐mediated …

The most abundant homomeric nicotinic acetylcholine receptors (nAChRs) in the
mammalian brain are the pentameric α7 nAChRs which consist of five α7 subunits, and each …

A novel α7 nAChR agonist, 4-(5-methyloxazolo [4, 5-b] pyridin-2-yl)-1, 4-diazabicyclo [3.2. 2]
nonane (24, CP-810,123), has been identified as a potential treatment for cognitive deficits …

Allosteric potentiation of acetylcholine nicotinic receptors is considered to be one of the most
promising approaches for the treatment of Alzheimer's disease. However, the exact …

Objective To evaluate the association of second-hand smoke exposure of pregnant mothers
using urine cotinine with the neurodevelopment of their children at 18 months of age in the …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a diverse class of ligand-gated ion
channels involved in neurological conditions such as neuropathic pain and Alzheimer's …

The neuronal nicotinic acetylcholine receptors (nAChR) are involved in functional processes
in brain including cognitive function and memory. A severe loss of the nAChRs has been …

Depression is associated with impairments to cognition and brain function at any age, but
such impairments in the elderly are particularly problematic because of the additional …

Utilizing the intrinsic optical signal (IOS) of retinal Spreading Depression (rSD) waves and
the concomitant transparency changes of the tissue, we show that nicotine, in an in vivo near …

This chapter focuses on the chemical make-up of brain, the endogenous agents involved in
CNS such as acetylcholine, catecholamines including dopamine, norepinephrine and …