Type 2B von Willebrand disease (VWD2B) is caused by an abnormal von Willebrand factor
(VWF) with increased affinity for the platelet receptor glycoprotein Ib-α (GPIb-α) that may …

The ubiquitin-mediated proteolysis of the Cdk2 inhibitor p27 Kip1 plays a central role in cell
cycle progression, and enhanced degradation of p27 Kip1 is associated with many common …

Cooling of blood platelets clusters the von Willebrand factor receptor complex. Macrophage
αMβ2 integrins bind to the GPIbα subunit of the clustered complex, resulting in rapid …

Although surface sialic acid is considered a key determinant for the survival of circulating
blood cells and glycoproteins, its role in platelet circulation lifetime is not fully clarified. We …

The variable lymphocyte receptors (VLRs) of jawless vertebrates such as lamprey and
hagfish are composed of highly diverse modular leucine-rich repeats. Each lymphocyte …

Glycoprotein (GP) Ib–IX–V is a remarkable platelet adhesion receptor of the leucine-rich
repeat family. It has evolved to fulfil its major function of initiating platelet aggregation …

Von Willebrand factor (VWF) activates in response to shear flow to initiate hemostasis, while
aberrant activation could lead to thrombosis. Above a critical shear force, the A1 domain of …

ABSTRACT LRR-containing proteins are present in over 2000 proteins from viruses to
eukaryotes. Most LRRs are 20–30 amino acids long, and the repeat number ranges from 2 …

Genetic defects of the megakaryocyte lineage give rise to bleeding syndromes of varying
severity. Blood platelets are unable to fulfill their hemostatic function of preventing blood loss …

Platelets play a central role in maintaining hemostasis mainly by binding to subendothelial
collagen exposed upon vascular injury, thereby initiating thrombus formation. Platelets can …