Background: Platelet-neutrophil interactions contribute to vascular occlusion and tissue
damage in thromboinflammatory disease. Platelet glycoprotein Ibα (GPIbα), a key receptor …

Abstract How glycoprotein (GP) Ib-IX complex on the platelet surface senses the blood flow
through its binding to the plasma protein von Willebrand factor (VWF) and transmits a signal …

Abstract The glycoprotein (GP) Ib‐IX receptor complex plays a critical role in platelet
physiology and pathology. Its interaction with von Willebrand factor (VWF) on the …

Leucine-rich repeat containing proteins are involved in protein–protein interactions and they
regulate numerous cellular events during nervous system development and disease. Here …

Protein A (Spa) is a surface‐associated protein of Staphylococcus aureus best known for its
ability to bind to the Fc region of IgG. Spa also binds strongly to the Fab region of the …

It is widely accepted that glycoprotein (GP) Ib contains one Ibα and one Ibβ subunit that are
connected by a disulfide bond. It is unclear which Cys residue in Ibα, C484 or C485, forms …

The mechanisms by which von Willebrand factor (VWF) achieves hemostasis lie in its
structure. Whereas low-molecular-weight forms have diminished hemostatic potential …

Direct interaction between platelet receptor glycoprotein Ibα (GpIbα) and thrombin is
required for platelet aggregation and activation at sites of vascular injury. Abnormal GpIbα …

Soluble von Willebrand factor (VWF) has a low affinity for platelet glycoprotein (GP) Ibα and
needs immobilization and/or high shear stress to enable binding of its A1 domain to the …

Abstract The glycoprotein (GP) Ib-IX complex is a platelet receptor that mediates the initial
interaction with subendothelial von Willebrand factor (VWF) causing platelet arrest at sites of …