Alzheimer's disease: molecular aspects and treatment opportunities using herbal drugs

S Thakral, A Yadav, V Singh, M Kumar, P Kumar… - Ageing Research …, 2023 - Elsevier
Abstract Alzheimer's disease (AD), also called senile dementia, is the most common
neurological disorder. Around 50 million people, mostly of advanced age, are suffering from …

[HTML][HTML] Mechanisms of ferroptosis in Alzheimer's disease and therapeutic effects of natural plant products: A review

D Zhao, K Yang, H Guo, J Zeng, S Wang, H Xu… - Biomedicine & …, 2023 - Elsevier
Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by
massive loss of specific neurons. It is a progressive disabling, severe and fatal complex …

Cellular metabolism: a fundamental component of degeneration in the nervous system

K Maiese - Biomolecules, 2023 - mdpi.com
It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …

[HTML][HTML] Gallic acid and hesperidin elevate neurotransmitters level and protect against oxidative stress, inflammation and apoptosis in aluminum chloride-induced …

BE Ekundayo, TO Obafemi, BA Afolabi… - Pharmacological …, 2022 - Elsevier
Abstract Background/Aim Gallic acid and metformin are plant-derived compounds with
biological effects. The present study aimed to evaluate the protective effect of gallic acid and …

The implications of telomere length: advanced aging, cell senescence, mri phenotypes, stem cells and alzheimer's disease

K Maiese - Current Neurovascular Research, 2023 - ingentaconnect.com
Telomeres (TLs) reside at the end of chromosomes and are complexes of deoxyribonucleic
acid (DNA). TLs oversee cell replication and the lifespan of a cell, are involved in multiple …

[HTML][HTML] The metabolic basis for nervous system dysfunction in alzheimer's disease, parkinson's disease, and huntington's disease

K Maiese - Current neurovascular research, 2023 - ncbi.nlm.nih.gov
Disorders of metabolism affect multiple systems throughout the body, but may have the
greatest impact on both central and peripheral nervous systems. Current available …

Apolipoprotein-4 allele (APOE-4) as a Mediator of Cognitive Loss and Dementia in Long COVID-19

K Maiese - Current Neurovascular Research, 2022 - ingentaconnect.com
The sporadic form of Alzheimer's disease (AD) represents most of the clinical cases for AD
and at least ten percent of the global population over the age of 65 are affected by sporadic …

Ferroptosis, iron metabolism, and forkhead transcription factors (Foxos)

K Maiese - Current Neurovascular Research, 2023 - ingentaconnect.com
Iron metabolism in the body is a critical process for sustaining life as well as determining cell
fate [1-4]. As an essential element, iron in the ferrous state (Fe2+) is an electron donor but in …

Mapping new pharmacological interventions for cognitive function in Alzheimer's disease: a systematic review of randomized clinical trials

I Xu Lou, J Chen, K Ali, AL Shaikh… - Frontiers in Pharmacology, 2023 - frontiersin.org
Background and Objective: Alzheimer's disease (AD) is a progressive neurodegenerative
disorder, that is, characterized by cognitive decline. To date, there are no effective …

[HTML][HTML] The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

K Maiese - Frontiers in Immunology, 2023 - frontiersin.org
Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …