Pongamol Prevents Neurotoxicity via the Activation of MAPKs/Nrf2 Signaling Pathway in H2O2-Induced Neuronal PC12 Cells and Prolongs the Lifespan of …

S Wu, J Miao, S Zhu, X Wu, J Shi, J Zhou, Y Xing… - Molecular …, 2024 - Springer
Despite tremendous advances in modern medicine, effective prevention or therapeutic
strategies for age-related neurodegenerative diseases such as Alzheimer's disease (AD) …

Neuroprotective effect of the traditional decoction Tian-Si-Yin against Alzheimer's disease via suppression of neuroinflammation

L Zhou, C Yang, Z Liu, L Chen, P Wang, Y Zhou… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Alzheimer's disease (AD) is the most prevalent
neurodegenerative disease among old adults. As a traditional Chinese medicine, the herbal …

[HTML][HTML] Innovative therapeutic strategies for cardiovascular disease

K Maiese - EXCLI journal, 2023 - ncbi.nlm.nih.gov
As a significant non-communicable disease, cardiovascular disease is the leading cause of
death for both men and women, comprises almost twenty percent of deaths in most racial …

Spectrum-effect relationship analysis based on HPLC-FT-ICR-MS and multivariate statistical analysis to reveal the pharmacodynamic substances of Ling-Gui-Zhu-Gan …

S Li, Y Sun, Y Gao, X Yu, C Zhao, X Song… - … of Pharmaceutical and …, 2024 - Elsevier
Alzheimer's disease (AD) threatens elderly human health and still lacks effective treatment.
Our previous work showed that LGZGD possessed a neuroprotective effect on the Aβ 25–35 …

Cognitive impairment in multiple sclerosis

K Maiese - Bioengineering, 2023 - mdpi.com
Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a
demyelinating disease in the nervous system with increased prevalence over the last five …

Efficacy evaluation and metabolomics analysis of Huanglian Jiedu decoction in combination with donepezil for Alzheimer's disease treatment

M Xu, Y Yue, J Huang - Journal of Pharmaceutical and Biomedical Analysis, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive disease with continuous brain changes and has
caused a severe burden on families and society. Huanglian Jiedu Decoction (HLJD) is a …

Pongamol Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer's Disease by Regulating the Akt/mTOR Signaling Pathway

K Hu, S Wu, J Xu, Y Zhang, Y Zhang, X Wu… - Journal of Agricultural …, 2024 - ACS Publications
Alzheimer's disease (AD), one of the neurodegenerative disorders, is highly correlated with
the abnormal hyperphosphorylation of Tau and aggregation of β-amyloid (Aβ). Oxidative …

Mechanism interpretation of Guhan Yangshengjing for protection against Alzheimer's disease by network pharmacology and molecular docking

S Cheung, Y Zhong, L Wu, X Jia, MQ He, Y Ai… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Guhan Yangshengjing (GHYSJ) is an effective
prescription for delaying progression of Alzheimer's disease (AD) based on the ancient …

Cornerstone Cellular Pathways for Metabolic Disorders and Diabetes Mellitus: Non-Coding RNAs, Wnt Signaling, and AMPK

K Maiese - Cells, 2023 - mdpi.com
Metabolic disorders and diabetes (DM) impact more than five hundred million individuals
throughout the world and are insidious in onset, chronic in nature, and yield significant …

Classic famous prescription kai-xin-san ameliorates alzheimer's disease via the wnt/β-catenin signaling pathway

X Shan, S Lv, P Huang, W Zhang, C Jin, Y Liu… - Molecular …, 2024 - Springer
Abstract Kai-Xin-San (KXS) is a classic famous prescription composed of Polygalae Radix,
Ginseng Radix et Rhizoma, Acori Tatarinowii Rhizoma, and Poria. Clinically, KXS is effective …