In situ self-assembly for cancer therapy and imaging

J Kim, S Lee, Y Kim, M Choi, I Lee, E Kim… - Nature Reviews …, 2023 - nature.com
In situ self-assembly—the in situ formation of complex materials via biochemical reactions of
monomers—has enhanced the efficacy of drug delivery for cancer therapy and imaging. So …

Recent trends in molecular aggregates: An exploration of biomedicine

J Heo, DP Murale, HY Yoon, V Arun, S Choi, E Kim… - …, 2022 - Wiley Online Library
Molecular aggregates are receiving tremendous attention, demonstrating immense potential
for biomedical applications in vitro and in vivo. For instance, the molecular aggregates of …

Carbon quantum dots-based nanozyme from coffee induces cancer cell ferroptosis to activate antitumor immunity

L Yao, MM Zhao, QW Luo, YC Zhang, TT Liu, Z Yang… - ACS …, 2022 - ACS Publications
Carbon quantum dots (CQDs) offer huge potential due to their enzymatic properties as
compared to natural enzymes. Thus, discovery of CQDs-based nanozymes with low toxicity …

[HTML][HTML] Reactive oxygen species-responsive and Raman-traceable hydrogel combining photodynamic and immune therapy for postsurgical cancer treatment

Y Zhang, S Tian, L Huang, Y Li, Y Lu, H Li… - Nature …, 2022 - nature.com
Combining immune checkpoint blockade (ICB) therapy with photodynamic therapy (PDT)
holds great potential in treating immunologically “cold” tumors, but photo-generated reactive …

Amplification of activated near-infrared afterglow luminescence by introducing twisted molecular geometry for understanding neutrophil-involved diseases

C Chen, H Gao, H Ou, RTK Kwok, Y Tang… - Journal of the …, 2022 - ACS Publications
Understanding the mechanism and progression of neutrophil-involved diseases (eg, acute
inflammation) is of great importance. However, current available analytical methods neither …

Semiconducting polymer nanoparticles with surface‐mimicking protein secondary structure as lysosome‐targeting chimaeras for self‐synergistic cancer …

J Qi, S Jia, X Kang, X Wu, Y Hong, K Shan… - Advanced …, 2022 - Wiley Online Library
Immunotherapy has received tremendous attention for tumor treatment, but the efficacy is
greatly hindered by insufficient tumor‐infiltration of immune cells and immunosuppressive …

An Activatable Near‐Infrared Afterglow Theranostic Prodrug with Self‐Sustainable Magnification Effect of Immunogenic Cell Death

Z Gao, S Jia, H Ou, Y Hong, K Shan… - Angewandte Chemie …, 2022 - Wiley Online Library
Herein, we report an activatable near‐infrared (NIR) afterglow theranostic prodrug that
circumvents high background noise interference caused by external light excitation. The …

A Microenvironment Dual‐Responsive Nano‐Drug Equipped with PD‐L1 Blocking Peptide Triggers Immunogenic Pyroptosis for Prostate Cancer Self‐Synergistic …

H Wang, Z Gao, D Jiao, Y Zhang… - Advanced Functional …, 2023 - Wiley Online Library
Induction of immunogenic cell death (ICD) in tumor combined with immune checkpoint
blockade (ICB) therapy is widely developed to improve the efficacy of cancer …

Sonosensitized aggregation-induced emission dots with capacities of immunogenic cell death induction and multivalent blocking of programmed cell death-ligand 1 …

S Jia, Z Gao, Z Wu, H Gao, H Wang, H Ou… - CCS …, 2022 - chinesechemsoc.org
The combination of immunogenic cell death (ICD) induction and immune checkpoint
blockade has emerged as a major direction of cancer immunotherapy. Among currently …

Transformable ECM deprivation system effectively suppresses renal cell carcinoma by reversing anoikis resistance and increasing chemotherapy sensitivity

L Wang, C Li, J Wang, G Yang, Y Lv, B Fu… - Advanced …, 2022 - Wiley Online Library
Extracellular matrix (ECM) is crucial in various biological functions during tumor progression,
including induction of anoikis resistance and cell adhesion‐mediated drug resistance (CAM …