Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration

JD Quick, C Silva, JH Wong, KL Lim… - Journal of …, 2023 - Springer
Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Microglia and Alzheimer's disease

S Merighi, M Nigro, A Travagli, S Gessi - International Journal of …, 2022 - mdpi.com
There is a huge need for novel therapeutic and preventative approaches to Alzheimer's
disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The …

Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments

M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

The role of glial autophagy in Alzheimer's disease

A Litwiniuk, GR Juszczak, AM Stankiewicz… - Molecular …, 2023 - nature.com
Although Alzheimer's disease is the most pervasive neurodegenerative disorder, the
mechanism underlying its development is still not precisely understood. Available data …

[HTML][HTML] Alzheimer's disease puzzle: delving into pathogenesis hypotheses

M Nasb, W Tao, N Chen - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by both
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …

Microbiome dysbiosis: a pathological mechanism at the intersection of obesity and glaucoma

S Pezzino, M Sofia, LP Greco, G Litrico… - International Journal of …, 2023 - mdpi.com
The rate at which obesity is becoming an epidemic in many countries is alarming. Obese
individuals have a high risk of developing elevated intraocular pressure and glaucoma …

Biochemical and molecular pathways in neurodegenerative diseases: an integrated view

N Sanghai, GK Tranmer - Cells, 2023 - mdpi.com
Neurodegenerative diseases (NDDs) like Alzheimer's disease (AD), Parkinson's disease
(PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of complex …

Zebrafish: A model deciphering the impact of flavonoids on neurodegenerative disorders

K Mhalhel, M Sicari, L Pansera, J Chen, M Levanti… - Cells, 2023 - mdpi.com
Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have
spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate …

Microglia and astroglia—the potential role in neuroinflammation induced by pre-and neonatal exposure to lead (Pb)

M Gąssowska-Dobrowolska, M Chlubek… - International Journal of …, 2023 - mdpi.com
Neuroinflammation is one of the postulated mechanisms for Pb neurotoxicity. However, the
exact molecular mechanisms responsible for its pro-inflammatory effect are not fully …

Mind the gap: unraveling the intricate dance between Alzheimer's disease and related dementias and bone health

SJ Karnik, TJ Margetts, HS Wang, A Movila… - Current Osteoporosis …, 2024 - Springer
Abstract Purpose of Review This review examines the linked pathophysiology of Alzheimer's
disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis …