Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration
Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …
immune responses. They also provide a frontline of host defense in the central nervous …
Microglia and Alzheimer's disease
There is a huge need for novel therapeutic and preventative approaches to Alzheimer's
disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The …
disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The …
Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments
M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …
astrocytes participate in several pathophysiological processes including neuroinflammation …
The role of glial autophagy in Alzheimer's disease
A Litwiniuk, GR Juszczak, AM Stankiewicz… - Molecular …, 2023 - nature.com
Although Alzheimer's disease is the most pervasive neurodegenerative disorder, the
mechanism underlying its development is still not precisely understood. Available data …
mechanism underlying its development is still not precisely understood. Available data …
[HTML][HTML] Alzheimer's disease puzzle: delving into pathogenesis hypotheses
Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by both
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …
Microbiome dysbiosis: a pathological mechanism at the intersection of obesity and glaucoma
S Pezzino, M Sofia, LP Greco, G Litrico… - International Journal of …, 2023 - mdpi.com
The rate at which obesity is becoming an epidemic in many countries is alarming. Obese
individuals have a high risk of developing elevated intraocular pressure and glaucoma …
individuals have a high risk of developing elevated intraocular pressure and glaucoma …
Biochemical and molecular pathways in neurodegenerative diseases: an integrated view
N Sanghai, GK Tranmer - Cells, 2023 - mdpi.com
Neurodegenerative diseases (NDDs) like Alzheimer's disease (AD), Parkinson's disease
(PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of complex …
(PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of complex …
Zebrafish: A model deciphering the impact of flavonoids on neurodegenerative disorders
Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have
spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate …
spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate …
Microglia and astroglia—the potential role in neuroinflammation induced by pre-and neonatal exposure to lead (Pb)
M Gąssowska-Dobrowolska, M Chlubek… - International Journal of …, 2023 - mdpi.com
Neuroinflammation is one of the postulated mechanisms for Pb neurotoxicity. However, the
exact molecular mechanisms responsible for its pro-inflammatory effect are not fully …
exact molecular mechanisms responsible for its pro-inflammatory effect are not fully …
Mind the gap: unraveling the intricate dance between Alzheimer's disease and related dementias and bone health
Abstract Purpose of Review This review examines the linked pathophysiology of Alzheimer's
disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis …
disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis …