The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …

The heart is the first organ to form during embryonic development. Given the complex nature
of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital …

Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …

In 2014, an extensive review discussing the major steps of cardiac development focusing on
growth, formation of primary and chamber myocardium and the development of the cardiac …

The mammalian heart contains multiple cell types that appear progressively during
embryonic development. Advance in determining cardiac lineage diversification has often …

The heart is the first organ to be functional in the fetus. Heart formation is a complex
morphogenetic process regulated by both genetic and epigenetic mechanisms. Congenital …

Extensive studies have shown how bilateral symmetry of the vertebrate embryo is broken
during early development, resulting in a molecular left-right bias in the mesoderm. However …

Most animals show external bilateral symmetry, which hinders the observation of multiple
internal left–right (L/R) asymmetries that are fundamental to organ packaging and function …

Genetically modified mice have advanced our understanding of valve development and
disease. Yet, human pathophysiological valvulogenesis remains poorly understood. Here …

Congenital heart disease (CHD) is the most common birth defect among newborns
worldwide and contributes to significant infant morbidity and mortality. Owing to major …