Management of patients treated with direct oral anticoagulants in clinical practice and challenging scenarios

F Lucà, F Oliva, MG Abrignani, SA Di Fusco… - Journal of Clinical …, 2023 - mdpi.com
It is well established that direct oral anticoagulants (DOACs) are the cornerstone of
anticoagulant strategy in atrial fibrillation (AF) and venous thromboembolism (VTE) and …

Combination of antiplatelet and anticoagulant therapy, component network meta-analysis of randomized controlled trials

L Szapáry, D Tornyos, P Kupó, R Lukács… - Frontiers in …, 2022 - frontiersin.org
Background Despite numerous randomized clinical trials (RCT), data regarding the efficacy
of antiplatelet and anticoagulant combinations are still conflicting. We aimed to analyze …

Factor XIa inhibitors as a novel anticoagulation target: recent clinical research advances

Y Xia, Y Hu, L Tang - Pharmaceuticals, 2023 - mdpi.com
Background: While current clinically administered anticoagulant medications have
demonstrated effectiveness, they have also precipitated significant risks: severe bleeding …

Therapeutic potential of exosomes derived from circRNA_0002113 lacking mesenchymal stem cells in myocardial infarction

T Tian, F Li, R Chen, Z Wang, X Su… - Frontiers in Cell and …, 2022 - frontiersin.org
Exosomes are participated in the pathogenesis of cardiovascular diseases and can be
secreted by mesenchymal stem cells (MSCs). However, the effects of circRNA, delivered by …

Should atrial fibrillation be considered a vascular disease? The need for a comprehensive vascular approach

C Escobar-Cervantes, AP Reino… - Expert Review of …, 2023 - Taylor & Francis
Introduction Atrial fibrillation (AF) cannot be considered an isolated disease. Patients with AF
should be managed using a comprehensive approach that is not limited to stroke …

Vascular protection with rivaroxaban in the comprehensive management of atrial fibrillation

C Escobar-Cervantes, P Díez-Villanueva… - Expert Review of …, 2023 - Taylor & Francis
Introduction In addition to an increased risk of thromboembolic complications, patients with
atrial fibrillation (AF) are at risk for vascular events. Consequently, complete vascular …

[HTML][HTML] Trends in Off-Label Indications of Non-Vitamin K antagonist oral anticoagulants in acute coronary syndrome

R Kaddoura, B Orabi, MA Yassin… - Reviews in …, 2023 - imrpress.com
Acute coronary syndrome (ACS) is a leading cause of mortality worldwide. Despite optimal
antiplatelet therapy recommendation after ischemic events, recurrent thrombotic …

Non-vitamin K antagonist oral anticoagulants and risk of myocardial infarction in patients with atrial fibrillation with or without percutaneous coronary interventions: a …

S Grajek, M Kałużna-Oleksy, JM Siller-Matula… - Journal of Personalized …, 2021 - mdpi.com
The study aimed to assess the risk of myocardial infarction (MI) and major adverse cardiac
events during non-vitamin K antagonist oral anticoagulants (NOAC) compared to warfarin …

Antiplatelet aggregation properties of cirsilineol: a novel inhibitor of blood coagulation factor Xa

GO Kim, JB Heo, DH Park, GY Song, JS Bae - Pharmaceuticals, 2023 - mdpi.com
A small natural substance called cirsilineol (CSL), which was discovered in the plant
Artemisia vestita, is lethal to many cancer cells and has antioxidant, anticancer, and …

Differential drug target selection in blood coagulation: What can we get from computational systems biology models?

MA Panteleev, AA Andreeva… - Current Pharmaceutical …, 2020 - ingentaconnect.com
Discovery and selection of the potential targets are some of the important issues in
pharmacology. Even when all the reactions and the proteins in a biological network are …