Digital twins in pharmaceutical and biopharmaceutical manufacturing: a literature review
The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …
realization of digital twins (DT), which facilitates the transformation of the manufacturing …
A review on the modernization of pharmaceutical development and manufacturing–Trends, perspectives, and the role of mathematical modeling
Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …
use of outdated development and manufacturing technologies. The return on investment on …
[HTML][HTML] The future of pharmaceutical manufacturing sciences
J Rantanen, J Khinast - Journal of pharmaceutical sciences, 2015 - Elsevier
The entire pharmaceutical sector is in an urgent need of both innovative technological
solutions and fundamental scientific work, enabling the production of highly engineered …
solutions and fundamental scientific work, enabling the production of highly engineered …
Assessment of recent process analytical technology (PAT) trends: a multiauthor review
This multiauthor review article aims to bring readers up to date with some of the current
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …
trends in the field of process analytical technology (PAT) by summarizing each aspect of the …
Recent progress in continuous manufacturing of oral solid dosage forms
V Vanhoorne, C Vervaet - International Journal of Pharmaceutics, 2020 - Elsevier
Continuous drug product manufacturing is slowly being implemented in the pharmaceutical
industry. Although the benefits related to the quality and cost of continuous manufacturing …
industry. Although the benefits related to the quality and cost of continuous manufacturing …
Process analytical technology for continuous manufacturing of solid-dosage forms
M Fonteyne, J Vercruysse, F De Leersnyder… - TrAC Trends in …, 2015 - Elsevier
Currently, pharmaceutical production is making the switch from batch processing towards
continuous processing. The quality of intermediate and end products produced by batch …
continuous processing. The quality of intermediate and end products produced by batch …
Process analytical technology in continuous manufacturing of a commercial pharmaceutical product
JM Vargas, S Nielsen, V Cárdenas, A Gonzalez… - International journal of …, 2018 - Elsevier
The implementation of process analytical technology and continuous manufacturing at an
FDA approved commercial manufacturing site is described. In this direct compaction process …
FDA approved commercial manufacturing site is described. In this direct compaction process …
Recent advances in integrated process analytical techniques, modeling, and control strategies to enable continuous biomanufacturing of monoclonal antibodies
V Chopda, A Gyorgypal, O Yang… - Journal of Chemical …, 2022 - Wiley Online Library
Continuous bioprocessing is significantly changing the biological drugs (or biologics)
manufacturing landscape by potentially improving product quality, process stability, and …
manufacturing landscape by potentially improving product quality, process stability, and …
Process analysis and optimization of continuous pharmaceutical manufacturing using flowsheet models
Continuous manufacturing has attracted increasing research attention in the pharmaceutical
industry within the last decade. Based on the extensive experimental studies, numerous …
industry within the last decade. Based on the extensive experimental studies, numerous …
PAT implementation for advanced process control in solid dosage manufacturing–A practical guide
S Sacher, J Poms, J Rehrl, JG Khinast - International Journal of …, 2022 - Elsevier
The implementation of continuous pharmaceutical manufacturing requires advanced control
strategies rather than traditional end product testing or an operation within a small range of …
strategies rather than traditional end product testing or an operation within a small range of …