Assembly‐driven protection from hydrolysis as key selective force during chemical evolution

R Edri, S Fisher, C Menor‐Salvan, LD Williams… - FEBS …, 2023 - Wiley Online Library
The origins of biopolymers pose fascinating questions in prebiotic chemistry. The marvelous
assembly proficiencies of biopolymers suggest they are winners of a competitive …

The Role of Hydrogen Bonds in Thermally Responsive Crystallization‐Driven Template Autocatalysis

H Wu, QX Chen, Y Su, Z Chen - … Chemie International Edition, 2024 - Wiley Online Library
Autocatalysis has been recognized to be involved in the emergence of life and intrinsic to
biomolecular replication. Recently, an efficient template autocatalysis driven by solvent‐free …

Cysteine‐Based Dynamic Self‐Assembly and Their Importance in the Origins of Life

S Kuila, J Nanda - ChemSystemsChem, 2024 - Wiley Online Library
The knowledge regarding the origins of life from inanimate materials is still elusive. It was
proposed that biological building blocks evolved from the inorganic substances present in …

Stoichiometry alone can steer supramolecular systems on complex free energy surfaces with high selectivity

D Komáromy, T Tiemersma-Wegman, J Kemmink… - Chem, 2021 - cell.com
Self-assembly enables access to complex molecular architectures but is traditionally
confined to structures that represent global minima on the Gibbs energy landscape. We now …

Introducing charge transfer functionality into prebiotically relevant β-sheet peptide fibrils

D Ivnitski, M Amit, B Rubinov, R Cohen-Luria… - Chemical …, 2014 - pubs.rsc.org
Incorporation of naphthalene diimide moieties as side chains of short amphiphilic peptide
results in the formation of fibrils that exhibit substantial intermolecular π-stacking …

De Novo Designed α‐Helical Coiled‐Coil Peptides as Scaffolds for Chemical Reactions

WM Rink, F Thomas - Chemistry–A European Journal, 2019 - Wiley Online Library
Coiled coils (CCs) are well‐understood protein‐folding motifs. They appear in a variety of
oligomer states and as homo‐and heteromeric assemblies. This versatility and the general …

Phenylalanine-based fibrillar systems

S Kuila, S Dey, P Singh, A Shrivastava… - Chemical …, 2023 - pubs.rsc.org
Phenylketonuria (PKU) is an inborn metabolic disorder characterized by excess
accumulation of phenylalanine (Phe) and its fibril formation, resulting in progressive …

Sequence decoding of 1D to 2D self‐assembling cyclic peptides

S Díaz, I Insua, G Bhak… - Chemistry–A European …, 2020 - Wiley Online Library
The inherent ability of peptides to self‐assemble with directional and rationally predictable
interactions has fostered a plethora of synthetic two‐dimensional (2D) supramolecular …

The Systems Chemistry of Nucleic‐acid‐Peptide Networks

A Kumar Bandela, H Sadihov‐Hanoch… - Israel Journal of …, 2022 - Wiley Online Library
Living cells use chemical building blocks (biopolymers) to form fascinatingly complex
architectures, which in turn display multiple functions necessary for the cell life cycle. The …

Polymorphism in peptide self-assembly visualized

M Tirrell - Proceedings of the National Academy of …, 2022 - National Acad Sciences
The spontaneous formation of well-defined supramolecular structures, based on precisely
located, finely balanced, and weak, relative to kT, interactions among the assembling …