LKB1 loss of function is one key oncogenic event in lung cancer. Clinical data suggest that
LKB1 loss of function is associated with patients' smoking status. The responsible …

Background: The most abundant and potent carcinogenic tobacco-specific nitrosamine in
tobacco and tobacco smoke is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). In …

(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and carcinogenic
tobacco-specific nitrosamine in tobacco and tobacco smoke. The major metabolic pathway …

Menthol, which creates mint flavor and scent, is often added to tobacco in both menthol and
nonmenthol cigarettes. A potent tobacco carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1 …

Tobacco specific nitrosamines (TSNAs) are among the most potent carcinogens found in
cigarettes and smokeless tobacco products. Decreases in TSNA detoxification, particularly 4 …

Cigarette smoking and air pollution (particulate matter) are recognized as two major
etiological factors for lung cancer. Of all the risk factors, cigarette smoking is significantly …

School children may be exposed to secondhand smoke (SHS) either at home, in transit or in
social gatherings permitting smoking in their presence. Questionnaires about SHS often …

PROMISCUITY AND TISSUE-SPECIFIC FRACTIONAL CONTRIBUTION OF UGT2B17 TO
DRUG AND STEROID METABOLISM By DEEPAK AHIRE A dissertation Page 1 PROMISCUITY …

Smoking is associated with worse clinical outcomes for lung cancer patients. Cell-based
studies suggest that NNK (a tobacco specific carcinogen) promotes lung cancer …

Background: Self-reporting on smoking, which has been primarily used as a method for
measuring exposure to smoking, can lead to erroneous measurements, and self-reports may …