Reflux hypersensitivity, recently introduced by Rome IV as a new functional esophageal
disorder, is currently considered as the presence of typical heartburn symptoms in patients …

In Japan, with the increasing prevalence of gastroesophageal reflux disease (GERD) and
growing public interest, the Japanese Society of Gastroenterology issued Evidence-based …

The Rome criteria were amended as Rome IV. For functional esophageal disorders, the
exclusion criteria have been more specifically revised based on further understanding of …

OBJECTIVES: To assess the efficacy and safety of vonoprazan on heartburn symptoms in
patients with nonerosive reflux disease (NERD)(ClinicalTrials. gov: NCT02954848) …

The Rome IV diagnostic criteria delineates 5 functional esophageal disorders which include
functional chest pain, functional heartburn, reflux hypersensitivity, globus, and functional …

Heartburn is among the most common gastrointestinal symptoms presenting to both
generalist physicians and gastroenterologists. Heartburn that does not respond to traditional …

Objective Clinically, patients with proton pomp inhibitor (PPI)-resistant gastroesophageal
reflux disease (GERD) are very challenging to treat. The aim of this study was to determine …

Abstract Purpose of Review This paper aims to review the definition and diagnostic criteria
for reflux hypersensitivity and comment on the present and future management of this …

Background By means of 24 h multi-channel intraluminal impedance and pH recording
(MII/pH), patients with heartburn and normal upper gastrointestinal endoscopy findings can …

Gastroesophageal reflux disease (GERD) is caused by the reflux of gastric contents into the
esophagus due to a decline in esophageal clearance and anti-reflux barrier mechanisms …