In adult mammals, hematopoietic stem cells (HSCs) are defined by their abilities to self‐
renew and to differentiate to form all blood cell lineages. These rare multipotent cells occupy …

Fibroblastic stromal cells are as diverse, in origin and function, as the niches they fashion in
the mammalian body. This cellular variety impacts the spectrum of responses elicited by the …

Crosstalk between neighboring cells underlies many biological processes, including cell
signaling, proliferation and differentiation. Current single-cell genomic technologies profile …

With the 13th edition, Wintrobe's Clinical Hematology once again bridges the gap between
the clinical practice of hematology and the basic foundations of science. Broken down into …

Through their oxygen delivery function, red blood cells are pivotal to the healthy existence of
all vertebrate organisms. These cells are required during all stages of life—embryonic, fetal …

The cellular and molecular mechanisms by which a tumour cell undergoes metastasis to a
predetermined location are largely unknown. Here we demonstrate that bone marrow …

A role for macrophages in erythropoiesis was suggested several decades ago when
erythroblastic islands in the bone marrow, composed of a central macrophage surrounded …

Infusion of different hematopoietic stem cell populations and ex vivo expanded endothelial
progenitor cells augments neovascularization of tissue after ischemia and contributes to …

Hematopoietic stem cells (HSCs) give rise to all lineages of blood cells. Because HSCs must
persist for a lifetime, the balance between their proliferation and quiescence is carefully …

Tumor inflammation promotes angiogenesis, immunosuppression, and tumor growth, but the
mechanisms controlling inflammatory cell recruitment to tumors are not well understood. We …