Systems biology of malaria explored with nonhuman primates

MR Galinski - Malaria journal, 2022 - Springer
Abstract “The Primate Malarias” book has been a uniquely important resource for multiple
generations of scientists, since its debut in 1971, and remains pertinent to the present day …

Molecular markers for malaria genetic epidemiology: progress and pitfalls

S Ruybal-Pesántez, K McCann, J Vibin, S Siegel… - Trends in …, 2023 - cell.com
Over recent years, progress in molecular markers for genotyping malaria parasites has
enabled informative studies of epidemiology and transmission dynamics. Results have …

Drug resistance and vaccine target surveillance of Plasmodium falciparum using nanopore sequencing in Ghana

ST Girgis, E Adika, FE Nenyewodey… - Nature …, 2023 - nature.com
Malaria results in over 600,000 deaths annually, with the highest burden of deaths in young
children living in sub-Saharan Africa. Molecular surveillance can provide important …

Ancient diversity in host-parasite interaction genes in a model parasitic nematode

L Stevens, I Martínez-Ugalde, E King, M Wagah… - Nature …, 2023 - nature.com
Host-parasite interactions exert strong selection pressures on the genomes of both host and
parasite. These interactions can lead to negative frequency-dependent selection, a form of …

Genomics reveals heterogeneous Plasmodium falciparum transmission and selection signals in Zambia

AA Fola, Q He, S Xie, J Thimmapuram… - Communications …, 2024 - nature.com
Background Genomic surveillance is crucial for monitoring malaria transmission and
understanding parasite adaptation to interventions. Zambia lacks prior nationwide efforts in …

Population Genomic Evidence of Adaptive Response during the Invasion History of Plasmodium falciparum in the Americas

MJM Lefebvre, J Daron, E Legrand… - Molecular Biology …, 2023 - academic.oup.com
Plasmodium falciparum, the most virulent agent of human malaria, spread from Africa to all
continents following the out-of-Africa human migrations. During the transatlantic slave trade …

A Molecular Analysis of Memory B Cell and Antibody Responses Against Plasmodium falciparum Merozoite Surface Protein 1 in Children and Adults From Uganda

SJ Gonzales, KN Clarke, G Batugedara… - Frontiers in …, 2022 - frontiersin.org
Memory B cells (MBCs) and plasma antibodies against Plasmodium falciparum (Pf)
merozoite antigens are important components of the protective immune response against …

Measuring changes in Plasmodium falciparum var census population size and structure in response to sequential malaria control interventions

KE Tiedje, Q Zhan, S Ruybal-Pésantez, G Tonkin-Hill… - medRxiv, 2023 - medrxiv.org
The diversity of Plasmodium falciparum within human hosts requires parasite population
size be defined in terms of parasite variation rather than the number of infected hosts. To …

Transcriptomic analyses of differentially expressed human genes, micro RNAs and long-non-coding RNAs in severe, symptomatic and asymptomatic malaria infection

MA Oboh, OB Morenikeji, O Ojurongbe, BN Thomas - Scientific Reports, 2024 - nature.com
Malaria transmission and endemicity in Africa remains hugely disproportionate compared to
the rest of the world. The complex life cycle of P. falciparum (Pf) between the vertebrate …

Nanopore sequencing for real-time genomic surveillance of Plasmodium falciparum

ST Girgis, E Adika, FE Nenyewodey, DK Senoo Jnr… - bioRxiv, 2022 - biorxiv.org
Malaria is a global public health priority causing over 600,000 deaths annually, mostly
young children living in Sub-Saharan Africa. Molecular surveillance can provide key …