[HTML][HTML] Neuroinflammation in Parkinson's disease–putative pathomechanisms and targets for disease-modification

A Grotemeyer, RL McFleder, J Wu… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is a progressive and debilitating chronic disease that affects more
than six million people worldwide, with rising prevalence. The hallmarks of PD are motor …

[HTML][HTML] Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches

M Vidović, MG Rikalovic - Cells, 2022 - mdpi.com
Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

[HTML][HTML] Neurodegeneration by α-synuclein-specific T cells in AAV-A53T-α-synuclein Parkinson's disease mice

AA Karikari, RL McFleder, E Ribechini, R Blum… - Brain, behavior, and …, 2022 - Elsevier
Background Antigen-specific neuroinflammation and neurodegeneration are characteristic
for neuroimmunological diseases. In Parkinson's disease (PD) pathogenesis, α-synuclein is …

Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics

D Yadav, P Kumar - Neurochemistry international, 2022 - Elsevier
Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …

[HTML][HTML] Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective

S Yi, L Wang, H Wang, MS Ho, S Zhang - International Journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …

β-adrenoreceptors and the risk of Parkinson's disease

F Hopfner, GU Höglinger, G Kuhlenbäumer… - The Lancet …, 2020 - thelancet.com
Background β-adrenoceptors are widely expressed in different human organs, mediate
important body functions and are targeted by medications for various diseases (such as …

[HTML][HTML] Current treatments and new, tentative therapies for Parkinson's disease

T Pardo-Moreno, V García-Morales, S Suleiman-Martos… - Pharmaceutics, 2023 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative pathology, the origin of which is
associated with the death of neuronal cells involved in the production of dopamine. The …

[HTML][HTML] The Impact of SNCA Variations and Its Product Alpha-Synuclein on Non-Motor Features of Parkinson's Disease

L Magistrelli, E Contaldi, C Comi - Life, 2021 - mdpi.com
Parkinson's disease (PD) is a common and progressive neurodegenerative disease, caused
by the loss of dopaminergic neurons in the substantia nigra pars compacta in the midbrain …

[HTML][HTML] Polymorphisms of dopamine receptor genes and Parkinson's disease: clinical relevance and future perspectives

L Magistrelli, M Ferrari, A Furgiuele, AV Milner… - International journal of …, 2021 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disease caused by loss of dopaminergic
neurons in the midbrain. PD is clinically characterized by a variety of motor and nonmotor …

[HTML][HTML] Drug reprofiling history and potential therapies against Parkinson's disease

K Latif, A Ullah, AD Shkodina, DI Boiko… - Frontiers in …, 2022 - frontiersin.org
Given the high whittling down rates, high costs, and moderate pace of new medication,
revelation, and improvement, repurposing “old” drugs to treat typical and uncommon …