[HTML][HTML] Neuroinflammation in Parkinson's disease–putative pathomechanisms and targets for disease-modification
A Grotemeyer, RL McFleder, J Wu… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is a progressive and debilitating chronic disease that affects more
than six million people worldwide, with rising prevalence. The hallmarks of PD are motor …
than six million people worldwide, with rising prevalence. The hallmarks of PD are motor …
[HTML][HTML] Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches
M Vidović, MG Rikalovic - Cells, 2022 - mdpi.com
Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …
[HTML][HTML] Neurodegeneration by α-synuclein-specific T cells in AAV-A53T-α-synuclein Parkinson's disease mice
AA Karikari, RL McFleder, E Ribechini, R Blum… - Brain, behavior, and …, 2022 - Elsevier
Background Antigen-specific neuroinflammation and neurodegeneration are characteristic
for neuroimmunological diseases. In Parkinson's disease (PD) pathogenesis, α-synuclein is …
for neuroimmunological diseases. In Parkinson's disease (PD) pathogenesis, α-synuclein is …
Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics
Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …
[HTML][HTML] Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective
S Yi, L Wang, H Wang, MS Ho, S Zhang - International Journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …
β-adrenoreceptors and the risk of Parkinson's disease
F Hopfner, GU Höglinger, G Kuhlenbäumer… - The Lancet …, 2020 - thelancet.com
Background β-adrenoceptors are widely expressed in different human organs, mediate
important body functions and are targeted by medications for various diseases (such as …
important body functions and are targeted by medications for various diseases (such as …
[HTML][HTML] Current treatments and new, tentative therapies for Parkinson's disease
T Pardo-Moreno, V García-Morales, S Suleiman-Martos… - Pharmaceutics, 2023 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative pathology, the origin of which is
associated with the death of neuronal cells involved in the production of dopamine. The …
associated with the death of neuronal cells involved in the production of dopamine. The …
[HTML][HTML] The Impact of SNCA Variations and Its Product Alpha-Synuclein on Non-Motor Features of Parkinson's Disease
L Magistrelli, E Contaldi, C Comi - Life, 2021 - mdpi.com
Parkinson's disease (PD) is a common and progressive neurodegenerative disease, caused
by the loss of dopaminergic neurons in the substantia nigra pars compacta in the midbrain …
by the loss of dopaminergic neurons in the substantia nigra pars compacta in the midbrain …
[HTML][HTML] Polymorphisms of dopamine receptor genes and Parkinson's disease: clinical relevance and future perspectives
L Magistrelli, M Ferrari, A Furgiuele, AV Milner… - International journal of …, 2021 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disease caused by loss of dopaminergic
neurons in the midbrain. PD is clinically characterized by a variety of motor and nonmotor …
neurons in the midbrain. PD is clinically characterized by a variety of motor and nonmotor …
[HTML][HTML] Drug reprofiling history and potential therapies against Parkinson's disease
Given the high whittling down rates, high costs, and moderate pace of new medication,
revelation, and improvement, repurposing “old” drugs to treat typical and uncommon …
revelation, and improvement, repurposing “old” drugs to treat typical and uncommon …