Dendritic cells pulsed with gp96-peptide complexes derived from human hepatocellular carcinoma (HCC) induce specific cytotoxic T lymphocytes

XH Wang, Y Qin, MH Hu, Y Xie - Cancer Immunology, Immunotherapy, 2005 - Springer
Dendritic cells (DCs) are one of the most potent antigen-presenting cells (APCs) capable of
activating immune responses. Different forms of tumor antigens have been used to load DCs …

The polymorphisms of LCR, E6, and E7 of HPV-58 isolates in Yunnan, Southwest China

J Xi, J Chen, M Xu, H Yang, S Wen, Y Pan, X Wang… - Virology journal, 2018 - Springer
Abstract Backgroud Variations in HPV LCR/E6/E7 have been shown to be associated with
the viral persistence and cervical cancer development. So far, there are few reports about …

Immunology of human papillomavirus infection in lower genital tract neoplasia

S Man, A Fiander - Best Practice & Research Clinical Obstetrics & …, 2001 - Elsevier
Despite its being a relatively common virus, the study of human papillomavirus infection has
lagged behind that of other viruses. Human papillomaviruses do not provoke strong …

HPV induced cervical carcinogenesis: molecular basis and vaccine development

AM Kaufmann, C Backsch… - Zentralblatt für …, 2002 - thieme-connect.com
Prädisponierend für die Entstehung eines Zervixkarzinoms ist die Infektion mit humanen
„high-risk” Papillomviren (HPV). Es gibt nur wenige Zervixkarzinome, bei denen keine HPV …

Cervical cancer vaccines: progress and prospects

MA Steller - Journal of the Society for Gynecologic …, 2002 - journals.sagepub.com
Cervical cancer remains a leading cause of cancer-related mortality in women, particularly
in developing countries. The causal association between genital human papillomavirus …

Prophylactic, therapeutic and anti-metastatic effects of an HPV-16 mE6Δ/mE7/TBhsp70Δ fusion protein vaccine in an animal model

X Qian, Y Lu, Q Liu, K Chen, Q Zhao, J Song - Immunology letters, 2006 - Elsevier
Human papillomaviruses (HPVs), particularly HPV-16, are not only causally linked to
cervical cancers but also play an important role in the development of other cancers. The …

HPV16-specific cytotoxic T lymphocyte responses are detected in all HPV16-positive cervical cancer patients

V Valdespino, C Gorodezky, V Ortiz, AM Kaufmann… - Gynecologic …, 2005 - Elsevier
OBJECTIVES.: The specific CTL response against human papillomavirus (HPV) antigens in
women with cervical cancer has been poorly studied. Immunological monitoring of this …

Cross‐typic specificity and immunotherapeutic potential of a human HPV16 E7‐specific CTL line

SJ Youde, CM McCarthy, KJ Thomas… - … Journal of Cancer, 2005 - Wiley Online Library
Cervical cancer (CaCx) is strongly associated with human papillomavirus (HPV) infection,
particularly HPV types 16 and 18. The constitutive expression of HPV E6 and E7 proteins in …

Detection of CD8+ T cell responses to human papillomavirus type 16 antigens in women using imiquimod as a treatment for high-grade vulval intraepithelial neoplasia

RW Todd, JC Steele, I Etherington, DM Luesley - Gynecologic oncology, 2004 - Elsevier
Objectives. To investigate CD8+ T cell reactivity to human papillomavirus (HPV) 16 antigens
in patients with high-grade vulval intraepithelial neoplasia (VIN) before, during and after …

Therapeutic vaccination for the treatment of mucosotropic human papillomavirus-associated disease

NR Chu - Expert Opinion on Biological Therapy, 2003 - Taylor & Francis
There is a high prevalence of diseases caused by human papillomavirus (HPV) infection.
Unfortunately, current treatments are inadequate. However, because there is evidence to …