Iron acquisition systems of gram-negative bacterial pathogens define TonB-dependent pathways to novel antibiotics

PE Klebba, SMC Newton, DA Six, A Kumar… - Chemical …, 2021 - ACS Publications
Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …

Molecular strategies underlying Porphyromonas gingivalis virulence

IL Silva, E Cascales - Journal of Molecular Biology, 2021 - Elsevier
The anaerobic Gram-negative bacterium Porphyromonas gingivalis is considered the
keystone of periodontitis diseases, a set of inflammatory conditions that affects the tissues …

[HTML][HTML] Structure and function of stator units of the bacterial flagellar motor

M Santiveri, A Roa-Eguiara, C Kühne, N Wadhwa… - Cell, 2020 - cell.com
Many bacteria use the flagellum for locomotion and chemotaxis. Its bidirectional rotation is
driven by a membrane-embedded motor, which uses energy from the transmembrane ion …

Structures of the stator complex that drives rotation of the bacterial flagellum

JC Deme, S Johnson, O Vickery, A Aron… - Nature …, 2020 - nature.com
The bacterial flagellum is the prototypical protein nanomachine and comprises a rotating
helical propeller attached to a membrane-embedded motor complex. The motor consists of a …

Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry

DS Chorev, LA Baker, D Wu, V Beilsten-Edmands… - Science, 2018 - science.org
Membrane proteins reside in lipid bilayers and are typically extracted from this environment
for study, which often compromises their integrity. In this work, we ejected intact assemblies …

Structural basis for nutrient acquisition by dominant members of the human gut microbiota

AJ Glenwright, KR Pothula, SP Bhamidimarri… - Nature, 2017 - nature.com
The human large intestine is populated by a high density of microorganisms, collectively
termed the colonic microbiota, which has an important role in human health and nutrition …

[HTML][HTML] Heme uptake and utilization by gram-negative bacterial pathogens

KL Richard, BR Kelley, JG Johnson - Frontiers in cellular and …, 2019 - frontiersin.org
Iron is a transition metal utilized by nearly all forms of life for essential cellular processes,
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …

Pseudomonas aeruginosa and its multiple strategies to access iron

IJ Schalk, Q Perraud - Environmental Microbiology, 2023 - Wiley Online Library
Pseudomonas aeruginosa is a ubiquitous bacterium found in many natural and man‐made
environments. It is also a pathogen for plants, animals, and humans. As for almost all living …

The contribution of modern EPR to structural biology

G Jeschke - Emerging Topics in Life Sciences, 2018 - portlandpress.com
Electron paramagnetic resonance (EPR) spectroscopy combined with site-directed spin
labelling is applicable to biomolecules and their complexes irrespective of system size and …

The multifarious roles of Tol-Pal in Gram-negative bacteria

J Szczepaniak, C Press… - FEMS Microbiology …, 2020 - academic.oup.com
In the 1960s several groups reported the isolation and preliminary genetic mapping of
Escherichia coli strains tol erant towards the action of colicins. These pioneering studies kick …