Localization, tissue biology and T cell state—Implications for cancer immunotherapy

JM Schenkel, KE Pauken - Nature Reviews Immunology, 2023 - nature.com
Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …

Coxsackievirus and type 1 diabetes: diabetogenic mechanisms and implications for prevention

A Carré, F Vecchio, M Flodström-Tullberg… - Endocrine …, 2023 - academic.oup.com
The evidence for an association between coxsackievirus B (CVB) infection, pancreatic islet
autoimmunity, and clinical type 1 diabetes is increasing. Results from prospective cohorts …

[PDF][PDF] Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes

MK Rahim, TLH Okholm, KB Jones, EE McCarthy… - Cell, 2023 - cell.com
CD8+ T cell responses are critical for anti-tumor immunity. While extensively profiled in the
tumor microenvironment, recent studies in mice identified responses in lymph nodes (LNs) …

The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion

AM Globig, S Zhao, J Roginsky, VI Maltez, J Guiza… - Nature, 2023 - nature.com
CD8+ T cells are essential components of the immune response against viral infections and
tumours, and are capable of eliminating infected and cancerous cells. However, when the …

[PDF][PDF] A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity

P Meiser, MA Knolle, A Hirschberger, GP de Almeida… - Cancer Cell, 2023 - cell.com
Type 1 conventional dendritic cells (cDC1) can support T cell responses within tumors but
whether this determines protective versus ineffective anti-cancer immunity is poorly …

[PDF][PDF] Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

B Virassamy, F Caramia, P Savas, S Sant, J Wang… - Cancer Cell, 2023 - cell.com
CD8+ tumor-infiltrating lymphocytes with a tissue-resident memory T (T RM) cell phenotype
are associated with favorable prognosis in patients with triple-negative breast cancer …

Stem-like exhausted and memory CD8+ T cells in cancer

T Gebhardt, SL Park, IA Parish - Nature Reviews Cancer, 2023 - nature.com
T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …

[HTML][HTML] Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming

H Wu, X Zhao, SM Hochrein, M Eckstein… - Nature …, 2023 - nature.com
T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory
receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity …

[HTML][HTML] Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors

A Castiglioni, Y Yang, K Williams, A Gogineni… - Nature …, 2023 - nature.com
TGFβ signaling is associated with non-response to immune checkpoint blockade in patients
with advanced cancers, particularly in the immune-excluded phenotype. While previous …

[HTML][HTML] IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells

JM Mazet, JN Mahale, O Tong, RA Watson… - Nature …, 2023 - nature.com
IFNγ is an immune mediator with concomitant pro-and anti-tumor functions. Here, we
provide evidence that IFNγ directly acts on intra-tumoral CD8 T cells to restrict anti-tumor …