Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …

The evidence for an association between coxsackievirus B (CVB) infection, pancreatic islet
autoimmunity, and clinical type 1 diabetes is increasing. Results from prospective cohorts …

CD8+ T cell responses are critical for anti-tumor immunity. While extensively profiled in the
tumor microenvironment, recent studies in mice identified responses in lymph nodes (LNs) …

CD8+ T cells are essential components of the immune response against viral infections and
tumours, and are capable of eliminating infected and cancerous cells. However, when the …

Type 1 conventional dendritic cells (cDC1) can support T cell responses within tumors but
whether this determines protective versus ineffective anti-cancer immunity is poorly …

CD8+ tumor-infiltrating lymphocytes with a tissue-resident memory T (T RM) cell phenotype
are associated with favorable prognosis in patients with triple-negative breast cancer …

T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …

T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory
receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity …

TGFβ signaling is associated with non-response to immune checkpoint blockade in patients
with advanced cancers, particularly in the immune-excluded phenotype. While previous …

IFNγ is an immune mediator with concomitant pro-and anti-tumor functions. Here, we
provide evidence that IFNγ directly acts on intra-tumoral CD8 T cells to restrict anti-tumor …