[HTML][HTML] PPA1 promotes breast cancer proliferation and metastasis through PI3K/AKT/GSK3β signaling pathway

C Guo, S Li, A Liang, M Cui, Y Lou… - Frontiers in Cell and …, 2021 - frontiersin.org
Breast cancer is the most common malignancy among women. Inorganic pyrophosphatase
1 (PPA1) is a multifunctional protein involved in the development of several tumors …

[HTML][HTML] PPA1, an energy metabolism initiator, plays an important role in the progression of malignant tumors

S Wang, J Wei, S Li, Y Luo, Y Li, X Wang… - Frontiers in …, 2022 - frontiersin.org
Inorganic pyrophosphatase (PPA1) encoded by PPA1 gene belongs to Soluble
Pyrophosphatases (PPase) family and is expressed widely in various tissues of Homo …

[HTML][HTML] The emerging role of circular RNAs in cisplatin resistance in ovarian cancer: From Molecular mechanism to future potential

MM Mohammadi, H Rismanchi, A Farahani… - Non-coding RNA …, 2024 - Elsevier
Ovarian cancer (OC) is the most common cause of death in female cancers. The prognosis
of OC is very poor due to delayed diagnosis and identification of most patients in advanced …

Joint analysis of lncRNA m6A methylome and lncRNA/mRNA expression profiles in gastric cancer

Z Lv, L Sun, Q Xu, C Xing, Y Yuan - Cancer cell international, 2020 - Springer
Abstract Background N 6-methyladenosine (m 6 A) modification might be closely associated
with the genesis and development of gastric cancer (GC). Currently, the evidence …

The HNF1A-AS1/miR-92a-3p axis affects the radiosensitivity of non-small cell lung cancer by competitively regulating the JNK pathway

Z Wang, L Liu, Y Du, Y Mi, L Wang - Cell biology and toxicology, 2021 - Springer
Background It has been widely reported that long non-coding RNAs (lncRNAs) could affect
the varieties of tumor response to radiotherapy. LncRNA HNF1A-AS1 is transcribed from …

Circ_0067934 reduces JNK phosphorylation through a microRNA-545-3p/PPA1 axis to enhance tumorigenesis and cisplatin resistance in ovarian cancer

Y Yin, J Li, J Rong, B Zhang, X Wang… - Immunopharmacology …, 2022 - Taylor & Francis
Abstract Background Circular RNA 0067934 (circ_0067934) has been revealed as a cancer
driver in multiple human malignancies, whereas its action in the pathogenesis of ovarian …

Cold-inducible PPA1 is critical for the adipocyte browning in mice

Y Sun, J Yao, C Lu, N Yang, X Han, H Lin… - … and Biophysical Research …, 2023 - Elsevier
Promoting the thermogenic capacity of brown/beige adipocytes is becoming a promising
strategy to counteract obesity and related metabolic diseases. Inorganic pyrophosphatase 1 …

PPA1 promotes adipogenesis by regulating the stability of C/EBPs

Y Wu, Y Sun, Y Song, J Wang, Y Han, N Yang… - Cell Death & …, 2024 - nature.com
Adipogenesis significantly contributes to healthy adipose tissue expansion in obesity.
Increasing adipocyte number or function to alleviate adipose tissue overload could serve as …

TIFA promotes colorectal cancer cell proliferation in an RSK‐and PRAS40‐dependent manner

W Shen, W Du, Y Li, Y Huang, X Jiang, C Yang… - Cancer …, 2022 - Wiley Online Library
Previous studies have reported that TIFA plays different roles in various tumor types.
However, the function of TIFA in colorectal cancer (CRC) remains unclear. Here, we showed …

Current and future perspectives on the regulation and functions of miR-545 in cancer development

J Shen, X Su, Q Wang, Y Ke, T Zheng… - Cancer Pathogenesis …, 2023 - mednexus.org
Micro ribonucleic acids (miRNAs) are a highly conserved class of single-stranded non-
coding RNAs. Within the miR-545/374a cluster, miR-545 resides in the intron of the long non …