Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits

M Peiseler, R Schwabe, J Hampe, P Kubes… - Journal of …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …

Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Cirrhosis-associated immune dysfunction

A Albillos, R Martin-Mateos, S Van der Merwe… - Nature Reviews …, 2022 - nature.com
The term cirrhosis-associated immune dysfunction (CAID) comprises the distinctive
spectrum of immune alterations associated with the course of end-stage liver disease …

Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development

X Wang, Q He, C Zhou, Y Xu, D Liu, N Fujiwara… - Immunity, 2023 - cell.com
Obesity-induced chronic liver inflammation is a hallmark of nonalcoholic steatohepatitis
(NASH)—an aggressive form of nonalcoholic fatty liver disease. However, it remains unclear …

Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

Z Chen, R Tian, Z She, J Cai, H Li - Free Radical Biology and Medicine, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

[HTML][HTML] Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases

Y Song, J Liu, K Zhao, L Gao, J Zhao - Cell metabolism, 2021 - cell.com
High levels of cholesterol are generally considered to be associated with atherosclerosis. In
the past two decades, however, a number of studies have shown that excess cholesterol …

Role of liver sinusoidal endothelial cells in liver diseases

J Gracia-Sancho, E Caparrós… - Nature reviews …, 2021 - nature.com
Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis

S Kumar, Q Duan, R Wu, EN Harris, Q Su - Advanced drug delivery reviews, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease that encompasses a
spectrum of pathological conditions, ranging from simple steatosis (NAFL), nonalcoholic …

NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications

G Targher, CD Byrne, H Tilg - Gut, 2020 - gut.bmj.com
Non-alcoholic fatty liver disease (NAFLD) is a public health problem, affecting up to a third of
the world's adult population. Several cohort studies have consistently documented that …

The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease

LA Díaz, JP Arab, A Louvet, R Bataller… - Nature Reviews …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are the
leading causes of chronic liver disease worldwide. NAFLD and ALD share …