Background: Of all the psychiatric disorders associated with insomnia, depression is the
most common. It has been estimated that 90% of patients with depression complain about …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Objectives. This 2013 update of the practice guidelines for the biological treatment of
unipolar depressive disorders was developed by an international Task Force of the World …

These practical guidelines for the biological treatment of unipolar depressive disorders in
primary care settings were developed by an international Task Force of the World …

Aims To systematically review the literature on the efficacy and tolerability of the major
chronotherapeutic treatments of bipolar disorders (BD)—bright light therapy (LT), dark …

Total sleep deprivation (TSD) for one whole night improves depressive symptoms in 40–
60% of treatments. The degree of clinical change spans a continuum from complete …

The aim of this pilot study was to quantify the impact of sleep deprivation on
psychophysiological reactivity to emotional stimuli. Following an adaptation night of sleep in …

Background Although the words “fatigue” and “sleepiness” are often used interchangeably,
they are distinct phenomena. Sleepiness refers to a tendency to fall asleep, whereas fatigue …

Depressive syndromes are frequent and heterogeneous brain conditions with more than
90% of patients suffering from sleep complaints. Better characterizing this “sleep” domain …

Most organisms (including humans) developed daily rhythms in almost every aspect of their
body. It is not surprising that rhythms are also related to affect in health and disease. In the …