The role of m6A modification in the biological functions and diseases

X Jiang, B Liu, Z Nie, L Duan, Q Xiong, Z Jin… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal
cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells …

m6A RNA methylation: from mechanisms to therapeutic potential

PC He, C He - The EMBO journal, 2021 - embopress.org
RNA carries a diverse array of chemical modifications that play important roles in the
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the …

N6-adenosine methylation (m6A): a promising new molecular target in hypertension and cardiovascular diseases

A Paramasivam, J Vijayashree Priyadharsini… - Hypertension …, 2020 - nature.com
To the Editor: Epitranscriptomics is an emerging field of biology, in which post-transcriptional
modifications of RNA, as a novel mechanism discovered recently, are suggested to be a vital …

Role of m6A RNA methylation in cardiovascular disease

Y Qin, L Li, E Luo, J Hou, G Yan… - International …, 2020 - spandidos-publications.com
Abstract N6‑methyladenosine (m6A) is the most prevalent and abundant type of internal post‑
transcriptional RNA modification in eukaryotic cells. Multiple types of RNA, including …

Long noncoding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and …

ZQ Zheng, ZX Li, GQ Zhou, L Lin, LL Zhang, JW Lv… - Cancer research, 2019 - AACR
Long noncoding RNAs (lncRNA) play important roles in the tumorigenesis and progression
of cancers. However, the clinical significance of lncRNAs and their regulatory mechanisms …

Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

H Wang, X Hu, M Huang, J Liu, Y Gu, L Ma… - Nature …, 2019 - nature.com
Abstract N6-methyladenosine (m6A) modification plays important roles in various cellular
responses by regulating mRNA biology. However, how m6A modification is involved in …

Changes in m6A RNA methylation contribute to heart failure progression by modulating translation

T Berulava, E Buchholz, V Elerdashvili… - European journal of …, 2020 - Wiley Online Library
Aims Deregulation of epigenetic processes and aberrant gene expression are important
mechanisms in heart failure. Here we studied the potential relevance of m6A RNA …

RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent

X Wang, L Tian, Y Li, J Wang, B Yan, L Yang… - Journal of Experimental …, 2021 - Springer
Background Laryngeal cancer has the highest mortality rate among head and neck tumours.
RNA N6-methyladenosine (m6A) is the most plentiful and variable in mammalian mRNA …

METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury

L Wang, J Wang, P Yu, J Feng, G Xu, X Zhao… - Nature …, 2022 - nature.com
RNA m6A modification is the most widely distributed RNA methylation and is closely related
to various pathophysiological processes. Although the benefit of regular exercise on the …

[HTML][HTML] Targeting ferroptosis as a novel approach to alleviate aortic dissection

N Li, X Yi, Y He, B Huo, Y Chen, Z Zhang… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
A variety of programmed cell death types have been shown to participate in the loss of
smooth muscle cells (SMCs) during the development of aortic dissection (AD), but it is still …