mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification

R Kumari, P Ranjan, ZG Suleiman… - Cardiovascular …, 2022 - academic.oup.com
Among several known RNA modifications, N6‐methyladenosine (m6A) is the most studied
RNA epitranscriptomic modification and controls multiple cellular functions during …

[HTML][HTML] METTL3 plays multiple functions in biological processes

S Liu, L Zhuo, J Wang, Q Zhang, Q Li, G Li… - American journal of …, 2020 - ncbi.nlm.nih.gov
Abstract N 6-methyladenosine (m 6 A) is the most common internal modification of mRNAs
in higher eukaryotic. This process is performed by methyltransferase. Methyltransferase-like …

METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA

Z Wu, Y Shi, M Lu, M Song, Z Yu, J Wang… - Nucleic acids …, 2020 - academic.oup.com
Abstract N6-Methyladenosine (m6A) messenger RNA methylation is a well-known
epitranscriptional regulatory mechanism affecting central biological processes, but its …

[HTML][HTML] m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion

X Cao, Q Geng, D Fan, Q Wang, X Wang, M Zhang… - Molecular cancer, 2023 - Springer
Abstract N6-methyladenosine (m6A) methylation is the most universal internal modification
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …

The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA

XQ Gao, YH Zhang, F Liu, M Ponnusamy, XM Zhao… - Nature cell …, 2020 - nature.com
PIWI-interacting RNAs (piRNAs) are abundantly expressed during cardiac hypertrophy.
However, their functions and molecular mechanisms remain unknown. Here, we identified a …

Targeting age-related pathways in heart failure

H Li, MH Hastings, J Rhee, LE Trager, JD Roh… - Circulation …, 2020 - Am Heart Assoc
During aging, deterioration in cardiac structure and function leads to increased susceptibility
to heart failure. The need for interventions to combat this age-related cardiac decline is …

[HTML][HTML] Roles of RNA methylation on tumor immunity and clinical implications

M Zhang, J Song, W Yuan, W Zhang, Z Sun - Frontiers in immunology, 2021 - frontiersin.org
RNA methylation is a kind of RNA modification that exists widely in eukaryotes and
prokaryotes. RNA methylation occurs not only in mRNA but also in ncRNA. According to the …

[HTML][HTML] ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1

Z Han, X Wang, Z Xu, Y Cao, R Gong, Y Yu, Y Yu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract N 6-methyladenosine (m 6 A) RNA modification, a dynamic and reversible process,
is essential for tissue development and pathogenesis. However, the potential involvement of …

Naturally occurring modified ribonucleosides

PJ McCown, A Ruszkowska, CN Kunkler… - Wiley …, 2020 - Wiley Online Library
The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …

The N6-methyladenosine (m6A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA

Y Liu, Z Liu, H Tang, Y Shen, Z Gong… - … of Physiology-Cell …, 2019 - journals.physiology.org
Compelling evidence indicates that epigenetic regulations orchestrate dynamic macrophage
polarization. N 6-methyladenosine (m6A) methylation is the most abundant epigenetic …